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<p>A new series of macrocyclic complexes of lanthanum (III) derived from the template condensation reaction of bis(benzyl)-4-nitro-1,2-phenylene diamine with different diamines such as 4-nitro-1,2-phenylene diamine, 4-bromo-1,2-phenylene diamine, ethylene diamine, 1,2-diamino propane and 4-chloro-1,2-phenylene diamine in the presence of lanthanum chloride salt. The ligand was synthesized by the condensation of benzyl and 4-nitro-1,2 phenylene diamine. The synthesized complexes have been analyzed by elemental analysis, conductance measurement and characterized by spectral analysis, i.e. UV-visible, IR, <sup>1</sup>H-NMR, Mass, XRD and TGA techniques. The presence of sharp narrow peaks in the X-ray diffractogram confirmed the crystalline nature of the synthesized complexes. Antioxidant and Antidiabetic studies were performed for ligand and all complexes. The strongest antioxidant activity was recorded as 80% at 1000&#xa0;mg/L for [La(C<sub>40</sub>H<sub>26</sub>N<sub>5</sub>O<sub>2</sub>Cl<sub>2</sub>Br)]Cl.5H<sub>2</sub>O complex with IC<sub>50</sub> value of 203.9247&#xa0;mg/L. In addition to these, compounds were successfully also screened for their biological efficacies against a few pathogenic strains of bacteria and fungi.It was found that ligand and compexes show good antimicrobial results.</p>

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Synthesis and Characterization of Innovative Tetraazamacrocyclic Complexes of La(III) and their Antibacterial, Antifungal, Antioxidant and Antidiabetic Activity

  • 期刊论文

  • 发表日期：

    2025年8月27日

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  • Medha Babel,
  • Jaswant Raj,
  • Manish Kumar Yadav,
  • Nighat Fahmi,
  • Anita Kumari

摘要

A new series of macrocyclic complexes of lanthanum (III) derived from the template condensation reaction of bis(benzyl)-4-nitro-1,2-phenylene diamine with different diamines such as 4-nitro-1,2-phenylene diamine, 4-bromo-1,2-phenylene diamine, ethylene diamine, 1,2-diamino propane and 4-chloro-1,2-phenylene diamine in the presence of lanthanum chloride salt. The ligand was synthesized by the condensation of benzyl and 4-nitro-1,2 phenylene diamine. The synthesized complexes have been analyzed by elemental analysis, conductance measurement and characterized by spectral analysis, i.e. UV-visible, IR, 1H-NMR, Mass, XRD and TGA techniques. The presence of sharp narrow peaks in the X-ray diffractogram confirmed the crystalline nature of the synthesized complexes. Antioxidant and Antidiabetic studies were performed for ligand and all complexes. The strongest antioxidant activity was recorded as 80% at 1000 mg/L for [La(C40H26N5O2Cl2Br)]Cl.5H2O complex with IC50 value of 203.9247 mg/L. In addition to these, compounds were successfully also screened for their biological efficacies against a few pathogenic strains of bacteria and fungi.It was found that ligand and compexes show good antimicrobial results.