Scholarlink

<p>Breast cancer continues to be a complicated and pervasive health issue that impacts women worldwide. Fluorescent nanoparticles, in particular, provide significant potential for imaging and drug delivery in cancer cells. We describe the utilization of o-phenylenediamine carbon nanodots (OPD@CD) as fluorescent agents for in vitro imaging and drug delivery of breast cancer cells. The surface of OPD@CD was modified with the tyrosine kinase inhibition anticancer drug - erlotinib. The drug specifically targets human breast cancer cell lines (MCF-7) that overexpress the epidermal growth factor receptor (EGFR). The confocal luminescence microscopic photographs exhibit sufficient luminescence staining in MCF-7 cells.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Erlotinib-Conjugated O-Phenylenediamine Derived Fluorescent Carbon Nanodots (OPD@CD) Platform for Targeting Breast Cancer (MCF-7) Cells

  • 期刊论文

  • 发表日期：

    2025年4月7日

查看全文
  • Ali Ibrahim Shkhair,
  • Anju S. Madanan,
  • Susan Varghese,
  • Merin K. Abraham,
  • Geneva Indongo,
  • Greeshma Rajeevan,
  • Arathy B. K,
  • Sara Muneer Abbas,
  • Sony George

摘要

Breast cancer continues to be a complicated and pervasive health issue that impacts women worldwide. Fluorescent nanoparticles, in particular, provide significant potential for imaging and drug delivery in cancer cells. We describe the utilization of o-phenylenediamine carbon nanodots (OPD@CD) as fluorescent agents for in vitro imaging and drug delivery of breast cancer cells. The surface of OPD@CD was modified with the tyrosine kinase inhibition anticancer drug - erlotinib. The drug specifically targets human breast cancer cell lines (MCF-7) that overexpress the epidermal growth factor receptor (EGFR). The confocal luminescence microscopic photographs exhibit sufficient luminescence staining in MCF-7 cells.