A Comprehensive on Synthesis and Antimicrobial Evaluation of Substituted-Arylideneamino-5-(5-Chlorobenzofuran-2-yl)-1, 2, 4-Triazole-3-Thiol Derivatives/ Schiff Bases

Schiff bases are well known and popular classes of organic compounds containing imine (R₂C = NH) group that are widely used as catalysts and intermediates in numerous organic transformations. Schiff bases are medicinally very important because they exhibit antimicrobial like antibacterial, antiviral and anticancer activities. Benzofuran based Schiff bases have been found as interesting scaffolds for the synthesis and design of biologically active agents. Moreover, they possess a wide range of biological activities against fungal, bacterial, malarial, inflammatory and viral diseases. In this reviw, substituted-arylideneamino-5-(5-chlorobenzofuran-2-yl)-1,2,4-triazole-3-thiols have been synthesized by using efficient synthetic protocols. The synthesized derivatives are also evaluated against different bacterial strains.