<p>Methods to calculate cascades with prescribed concentrations of the target component of an isotope mixture in outgoing flows of the cascade have been developed. The methods made it possible to calculate squared-off cascades and cascades with a profiled feed flow of the stages. A computational experiment has been conducted on separation of a multicomponent mixture of germanium tetrafluoride and concentration of ⁷⁰Ge and ⁷⁶Ge in outgoing cascade flows. It has been shown that the proposed cascade with a profiled feed flow of the stages with optimum selection of its parameters differs little from the corresponding MARC, as far as the overall feed flow of the stages is concerned.</p>