<p>A generalized model of a quasi-ideal cascade with different values of the mass number of the reference component for different portions of the cascade has been proposed. A procedure has been developed to find such a set of parameters of the cascade at which one can ensure obtaining prescribed concentrations of the target components in its outgoing flows at prescribed integral numbers of stages in each of its sections.</p><p>A possibility has been shown to optimize this cascade for prescribed concentrations of the target component in outgoing flows through the exhaustion of different combinations of lengths of cascade sections with prescribed concentrations of the target component in its outgoing flows. The developed approach to optimizing a sectioned quasi-ideal cascade makes it possible to reduce the number of variables when the optimum parameters ensuring prescribed concentrations of the target component in the outgoing flows are assessed.</p>