<p>While safety is widely recognized as a foundational element of psychotherapy - supporting emotional regulation, exploration, and integration – a coherent, process-level model of how it is regulated throughout the therapeutic process remains underdeveloped. This article addresses that gap by offering a critical integration of developmental, relational, and neurobiological perspectives, and from this synthesis, proposes a transtheoretical approach that conceptualizes safety regulation as a core mechanism of therapeutic change. Safety regulation is not presented as a discrete phase or singular intervention but as a recursive, co-regulated process observable through distinct modes that adapt moment by moment to the client’s shifting emotional, cognitive, and physiological states. Therapeutic change is understood to unfold not in linear stages, but through cycles of stability and activation, with prior regulatory strategies revisited as part of developmental progress. Within this view, safety is not the absence of distress, but the medium through which tolerable dissonance and emotional intensity are metabolized - fostering resilience. To make this approach actionable, the article identifies basic recurring patterns – modes - of safety regulation that cut across therapeutic approaches. These modes show how therapists adjust stance, pacing, and proximity to match the client’s evolving regulatory needs and provide a procedural vocabulary to support moment-to-moment clinical decision-making. By enhancing conceptual understanding while offering practical guidance for therapeutic actions, this approach conceptualizes safety regulation as a dynamic process that scaffolds transformation.</p>