Scholarlink

<p>In response to the recent proposal by Monares-Zepeda et al. to estimate mean systemic filling pressure (MSFP) using cardiac power (CP) as a surrogate for the venous return pressure gradient (VRg), we raise concerns regarding the physiological validity and generalizability of the reported correlation. We demonstrate through simulation that the relationship between CP and VRg arises from structural mathematical coupling due to shared dependence on cardiac output (CO), and that this correlation weakens significantly (<i>r</i> = 0.54) when realistic physiological variability is introduced. We further argue that CP and VRg reflect distinct hemodynamic domains, and caution against interpreting their empirical correlation as evidence of physiological interchangeability. We call for broader validation of the model across diverse circulatory conditions. Comment on: ‘Presentation of a novel method to estimate analog mean systemic filling pressure based on cardiac power’ —on Correlation, Coupling, and Physiological Meaning.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comment on: ‘presentation of a novel method to estimate analog mean systemic filling pressure based on cardiac power’ —on correlation, coupling, and physiological meaning

  • 期刊论文

  • 发表日期：

    2025年8月25日

查看全文
  • Sebastián Faúndez,
  • Patricio López,
  • Ricardo Castro

摘要

In response to the recent proposal by Monares-Zepeda et al. to estimate mean systemic filling pressure (MSFP) using cardiac power (CP) as a surrogate for the venous return pressure gradient (VRg), we raise concerns regarding the physiological validity and generalizability of the reported correlation. We demonstrate through simulation that the relationship between CP and VRg arises from structural mathematical coupling due to shared dependence on cardiac output (CO), and that this correlation weakens significantly (r = 0.54) when realistic physiological variability is introduced. We further argue that CP and VRg reflect distinct hemodynamic domains, and caution against interpreting their empirical correlation as evidence of physiological interchangeability. We call for broader validation of the model across diverse circulatory conditions. Comment on: ‘Presentation of a novel method to estimate analog mean systemic filling pressure based on cardiac power’ —on Correlation, Coupling, and Physiological Meaning.