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<p>The rise of antibiotic-resistant bacterial infections presents a significant global health challenge, contributing to higher mortality rates and prolonged hospitalizations. A promising solution is the development of localized hyperthermia for bacterial inactivation. In this study, we investigate the fabrication of silver-coated upconversion nanoparticles (UCNP@Ag NPs) that convert near-infrared (NIR) light into localized heat, offering an alternative to traditional antibiotic treatments. UCNP@Ag NPs were successfully synthesized and showed high photothermal conversion efficiency when irradiated with a 980&#xa0;nm NIR laser. At a concentration of 100&#xa0;µg/mL, the nanoparticles increased the solution temperature to 58.9&#xa0;°C within 6&#xa0;min under 1.0&#xa0;W/cm² NIR laser irradiation, which was sufficient to kill the bacteria. The inhibition rates for E. coli and S. aureus were 96.2% and 93.9%, respectively. The core-shell nanostructure exhibited superior antibacterial performance compared to silver nanoparticles (Ag NPs) and non-irradiated groups. Additionally, density functional theory (DFT) calculations confirmed that the adsorption energy of Ag clusters on the NaYF₄:Yb, Tm host was thermodynamically favorable (− 1.23&#xa0;eV), ensuring stable integration. The calculated projected density of states (PDOS) and dielectric function analyses showed that Ag doping modifies the electronic structure near the Fermi level, enhancing NIR absorption and localized heating, which were critical for the nanoparticle’s effective antibacterial performance. The synergistic effect of UCNP@Ag NPs via combining Ag⁺-mediated antibacterial activity and photothermal hyperthermia which avoids latent bacterial activation and overcomes the limitations of single-modality antibiotic therapy. The synergy between the thermal and silver effects presents a promising alternative to traditional antibiotics, with potential applications in combating resistant bacterial strains.</p> Graphical Abstract <p></p>

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Synergistic Photothermal Antibacterial Effects of Silver-Coated Upconversion Nanoparticles: Experimental Insights and DFT Calculations

  • 期刊论文

  • 发表日期：

    2026年6月20日

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  • Zhou You,
  • Ali Mohsin,
  • Reesha Khan,
  • Ali Hussain,
  • Cao Wenbo,
  • Sobia Niazi,
  • Muhammad Sajjad,
  • Faizan ul Haq,
  • Ali Raza,
  • Khubaib Ali,
  • Muhammad Shoaib,
  • Ibrahim Khan,
  • Qi Shuo,
  • Imran Mahmood Khan

摘要

The rise of antibiotic-resistant bacterial infections presents a significant global health challenge, contributing to higher mortality rates and prolonged hospitalizations. A promising solution is the development of localized hyperthermia for bacterial inactivation. In this study, we investigate the fabrication of silver-coated upconversion nanoparticles (UCNP@Ag NPs) that convert near-infrared (NIR) light into localized heat, offering an alternative to traditional antibiotic treatments. UCNP@Ag NPs were successfully synthesized and showed high photothermal conversion efficiency when irradiated with a 980 nm NIR laser. At a concentration of 100 µg/mL, the nanoparticles increased the solution temperature to 58.9 °C within 6 min under 1.0 W/cm² NIR laser irradiation, which was sufficient to kill the bacteria. The inhibition rates for E. coli and S. aureus were 96.2% and 93.9%, respectively. The core-shell nanostructure exhibited superior antibacterial performance compared to silver nanoparticles (Ag NPs) and non-irradiated groups. Additionally, density functional theory (DFT) calculations confirmed that the adsorption energy of Ag clusters on the NaYF₄:Yb, Tm host was thermodynamically favorable (− 1.23 eV), ensuring stable integration. The calculated projected density of states (PDOS) and dielectric function analyses showed that Ag doping modifies the electronic structure near the Fermi level, enhancing NIR absorption and localized heating, which were critical for the nanoparticle’s effective antibacterial performance. The synergistic effect of UCNP@Ag NPs via combining Ag⁺-mediated antibacterial activity and photothermal hyperthermia which avoids latent bacterial activation and overcomes the limitations of single-modality antibiotic therapy. The synergy between the thermal and silver effects presents a promising alternative to traditional antibiotics, with potential applications in combating resistant bacterial strains.

Graphical Abstract