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<p>The study looked at a safe method to synthesize copper-zinc silicate nanoparticles (Cu-Zn Silicate NPs) using gum Arabic as green eco-friendly method. HRTEM imaging, Zeta potential, DLS assessment, EDX elemental analysis, FTIR analysis and SEM with mapping were used to validate the formed Cu-Zn Silicate NPs. The efficacy of Cu-Zn silicate NPs in inhibiting certain <i>Candida species</i> that cause wound infections was assessed by evaluating their capacity to stop their proliferation, the minimum amount needed to inhibit pathogenic yeast growth, and their ability to stop biofilm formation. To determine the kinetic analysis and possible mechanism of the antifungal response, the membrane leakage test was performed. In antifungal tests against <i>C. albicans</i>, the synthesized Cu-Zn silicate NPs possessed a promising zone of inhibition as 49.0 ± 0.2&#xa0;mm possessed a minimum inhibitory concentration (MIC) as 0.390&#xa0;µg/mL, 43.0 ± 0.3&#xa0;mm for <i>C. glabrata</i> as 0.781&#xa0;µg/mL MIC, and 31.0 ± 0.5&#xa0;mm for <i>C. krusei</i> as 6.250&#xa0;µg/mL MIC. Additionally, Cu-Zn silicate NPs active against <i>C. tropicalis</i> (26.0 ± 0.3&#xa0;mm ZOI with 12.50&#xa0;µg/mL MIC) and against <i>C. auris</i> (23.0 ± 0.2&#xa0;mm ZOI with 6.250&#xa0;µg/mL MIC). In antibiofilm test, <i>C. albicans</i> treated with Cu-Zn silicate NPs showed the most significant reduction in biofilm production as 96.23%, followed by <i>C. krusei</i> as 95.61%, and <i>C. glabrata</i> as 85.64%. The promising results indicated that the synthesized nanoparticles could be utilized against pathogenic yeasts, as the present research opens an exciting new phase for fighting the resistance of various diseases in biomedical areas like candidiasis.</p> Graphical Abstract <p></p>

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Green Synthesis, Characterization and Antifungal Potential of Inorganic Copper-Zinc Silicate Nanoparticles

  • 期刊论文

  • 发表日期：

    2026年3月7日

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  • Magdi E. A. Zaki,
  • Ibrahim Elbatal,
  • Roqayah Saleh Al-Habeeb,
  • Gharieb S. El-Sayyad,
  • Ahmed I. El-Batal

摘要

The study looked at a safe method to synthesize copper-zinc silicate nanoparticles (Cu-Zn Silicate NPs) using gum Arabic as green eco-friendly method. HRTEM imaging, Zeta potential, DLS assessment, EDX elemental analysis, FTIR analysis and SEM with mapping were used to validate the formed Cu-Zn Silicate NPs. The efficacy of Cu-Zn silicate NPs in inhibiting certain Candida species that cause wound infections was assessed by evaluating their capacity to stop their proliferation, the minimum amount needed to inhibit pathogenic yeast growth, and their ability to stop biofilm formation. To determine the kinetic analysis and possible mechanism of the antifungal response, the membrane leakage test was performed. In antifungal tests against C. albicans, the synthesized Cu-Zn silicate NPs possessed a promising zone of inhibition as 49.0 ± 0.2 mm possessed a minimum inhibitory concentration (MIC) as 0.390 µg/mL, 43.0 ± 0.3 mm for C. glabrata as 0.781 µg/mL MIC, and 31.0 ± 0.5 mm for C. krusei as 6.250 µg/mL MIC. Additionally, Cu-Zn silicate NPs active against C. tropicalis (26.0 ± 0.3 mm ZOI with 12.50 µg/mL MIC) and against C. auris (23.0 ± 0.2 mm ZOI with 6.250 µg/mL MIC). In antibiofilm test, C. albicans treated with Cu-Zn silicate NPs showed the most significant reduction in biofilm production as 96.23%, followed by C. krusei as 95.61%, and C. glabrata as 85.64%. The promising results indicated that the synthesized nanoparticles could be utilized against pathogenic yeasts, as the present research opens an exciting new phase for fighting the resistance of various diseases in biomedical areas like candidiasis.

Graphical Abstract