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<p>In this study, a green synthesis approach was employed to fabricate a chitosan-stabilized zinc and tin oxide nanocomposite (Ch-SnO₂-ZnO) using <i>Thippili fruit</i> extract in an aqueous medium. The Ch-SnO₂-ZnO NCs exhibited a crystalline size of approximately 56 nm. FESEM imaging revealed a closely packed polygonal morphology with an average particle size of 50 nm. Antibacterial evaluation demonstrated potent activity, with a maximum zone of inhibition of 22 mm against <i>Staphylococcus aureus</i> at a concentration of 2 mg/mL, showing dose-dependent bacterial growth suppression after 24 hours of incubation at 37 °C under visible light. The cytotoxicity assays revealed a marked reduction in the viability of glioblastoma (U87) cells in a dose-dependent for Ch-SnO₂-ZnO NCs. Biocompatibility studies were carried out using Zebra fish embryo model, testing with two different concentrations (1 and 3 mg/ mL) of Ch-SnO₂-ZnO NCs. These findings underscore the potential of green-synthesized Ch-SnO₂-ZnO NCs as a dual-action agent for combating brain cancer and associated microbial infections.</p>

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Bioactive and Biocompatible Chitosan-Tin Oxide-Zinc Oxide Nanocomposites Synthesized Via Thippili Extract for Dual Biomedical Applications

  • 期刊论文

  • 发表日期：

    2026年3月24日

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  • Manikandan S,
  • Arockia Sahayaraj P,
  • Sasi B,
  • Arulmanikandan Shanmugam,
  • Abdur Rahman M,
  • Venkadeshkumar Ramar

摘要

In this study, a green synthesis approach was employed to fabricate a chitosan-stabilized zinc and tin oxide nanocomposite (Ch-SnO₂-ZnO) using Thippili fruit extract in an aqueous medium. The Ch-SnO₂-ZnO NCs exhibited a crystalline size of approximately 56 nm. FESEM imaging revealed a closely packed polygonal morphology with an average particle size of 50 nm. Antibacterial evaluation demonstrated potent activity, with a maximum zone of inhibition of 22 mm against Staphylococcus aureus at a concentration of 2 mg/mL, showing dose-dependent bacterial growth suppression after 24 hours of incubation at 37 °C under visible light. The cytotoxicity assays revealed a marked reduction in the viability of glioblastoma (U87) cells in a dose-dependent for Ch-SnO₂-ZnO NCs. Biocompatibility studies were carried out using Zebra fish embryo model, testing with two different concentrations (1 and 3 mg/ mL) of Ch-SnO₂-ZnO NCs. These findings underscore the potential of green-synthesized Ch-SnO₂-ZnO NCs as a dual-action agent for combating brain cancer and associated microbial infections.