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<p>Novel Tin Dioxide-copper Oxide-Alginate <b>(</b>SnO<sub>2</sub>-CuO-SA) and Tin Dioxide-Nickel Oxide-Alginate <b>(</b>SnO<sub>2</sub>-NiO-SA) nanocomposites (NCs) were prepared using <i>Psidium guajava</i> (<i>P. guajava</i>) leaf extract. X-ray diffraction (XRD) confirmed the formation of tetragonal rutile phase with average crystallite size of 67.8&#xa0;nm and 58.1&#xa0;nm for SnO<sub>2</sub>-CuO-SA and SnO<sub>2</sub>-NiO-SA NCs, respectively. Field emission scanning electron microscope (FESEM) analysis shows, synthesis SnO<sub>2</sub>-CuO-SA and SnO<sub>2</sub>-NiO-SA NCs formed spherical structures, with an average particles 60.77&#xa0;nm and 41.59&#xa0;nm, respectively. X-ray photoelectron spectroscopic (XPS) studies showed that the SnO<sub>2</sub>-CuO-SA and SnO<sub>2</sub>-NiO-SA NCs contain exclusively of C <i>1s</i>, O <i>1s</i>, Sn <i>3d</i>, Cu <i>2p</i> and Ni <i>2p</i> oxidation state, respectively. The SnO<sub>2</sub>-NiO-SA NCs potential to inhibits both Gram-positive and Gram-negative strain as than SnO<sub>2</sub>-CuO-SA NCs. Moreover, the anticancer efficacy of NCs were tested using (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) MTT cell viability assay against Trible negative breast cancer cell (MDA-MB-231) lines. The SnO<sub>2</sub>-CuO-SA and SnO<sub>2</sub>-NiO-SA NCs exhibited IC<sub>50</sub> value of 8.8 and 5.8&#xa0;µg/mL, respectively. Antioxidant activity of SnO<sub>2</sub>-NiO-SA NCs have highest scavenging activity than SnO<sub>2</sub>-NiO-SA NCs. The results demonstrated that in vitro analysis showed SnO<sub>2</sub>-NiO-SA NCs could be promising therapeutic agents in antibacterial and anticancer treatment.</p>

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Bio-Inspired Synthesis of Dual Oxide-Alginate Nanocomposites Using Guava Leaf Extract for Antibacterial and Anticancer Applications

  • 期刊论文

  • 发表日期：

    2025年11月30日

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  • G. Balasubramaniyan,
  • G. Senthilkumar,
  • M. Abdur Rahman,
  • B. Sasi

摘要

Novel Tin Dioxide-copper Oxide-Alginate (SnO2-CuO-SA) and Tin Dioxide-Nickel Oxide-Alginate (SnO2-NiO-SA) nanocomposites (NCs) were prepared using Psidium guajava (P. guajava) leaf extract. X-ray diffraction (XRD) confirmed the formation of tetragonal rutile phase with average crystallite size of 67.8 nm and 58.1 nm for SnO2-CuO-SA and SnO2-NiO-SA NCs, respectively. Field emission scanning electron microscope (FESEM) analysis shows, synthesis SnO2-CuO-SA and SnO2-NiO-SA NCs formed spherical structures, with an average particles 60.77 nm and 41.59 nm, respectively. X-ray photoelectron spectroscopic (XPS) studies showed that the SnO2-CuO-SA and SnO2-NiO-SA NCs contain exclusively of C 1s, O 1s, Sn 3d, Cu 2p and Ni 2p oxidation state, respectively. The SnO2-NiO-SA NCs potential to inhibits both Gram-positive and Gram-negative strain as than SnO2-CuO-SA NCs. Moreover, the anticancer efficacy of NCs were tested using (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) MTT cell viability assay against Trible negative breast cancer cell (MDA-MB-231) lines. The SnO2-CuO-SA and SnO2-NiO-SA NCs exhibited IC50 value of 8.8 and 5.8 µg/mL, respectively. Antioxidant activity of SnO2-NiO-SA NCs have highest scavenging activity than SnO2-NiO-SA NCs. The results demonstrated that in vitro analysis showed SnO2-NiO-SA NCs could be promising therapeutic agents in antibacterial and anticancer treatment.