<p>The development of innovative biomaterials for effective gastric hemostasis is crucial for improving the management of gastrointestinal bleeding, a condition that poses significant clinical challenges. This study introduces melanin-augmented mangiferin-chitosan nanocomposites (M@Ch-Me NCs) as a multifunctional approach to achieving gastric hemostasis. These NCs combine the unique properties of chitosan, mangiferin, and melanin to address various aspects of gastric bleeding, including inflammation, oxidative stress, and tissue repair. Chitosan, a biocompatible and biodegradable polymer, serves as the structural foundation of the nanocomposite, providing mucoadhesive properties that facilitate targeted delivery and prolonged retention at the bleeding site. Mangiferin, a natural bioactive compound known for its antioxidant and anti-inflammatory properties, is incorporated to reduce oxidative damage and inflammation in the gastric mucosa. Melanin, a biopolymer with excellent free radical scavenging and photothermal conversion capabilities, augments the nanocomposite by enhancing its stability and therapeutic efficacy. The resulting M@Ch-Me NCs demonstrate significant potential for gastric hemostasis through their ability to promote blood clotting, reduce inflammation, and protect against oxidative stress. This multifunctional approach offers a promising strategy for the treatment of gastric bleeding, with potential applications in various clinical settings. Additional study and clinical trials are necessary to completely assess the effectiveness and wellbeing of these nanocomposites in human patients. </p> Graphical Abstract <p>Melanin-augmented mangiferin-chitosan nanocomposites exerts protective effects against gastric bleeding and gastric ulcers through multifunction approaches.</p> <p></p>