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<p>Mesoporous silica nanoparticles (MSNs) have been recently used in different biomedical applications such as antimicrobial alternatives, drug delivery, and bioimaging. MSNs might be synthesized via green synthesize techniques as a sustainable and environmentally friendly approach, to develop physical properties for nanomedicine applications. In this study, Resveratrol (Res) extract, a polyphenol, was used as the stable and reducing agent for the green synthesis of Res-templated Au-decorated MSNs. Several analytical techniques were used to characterize the samples, like scanning electron microscopy (SEM), brauer-emmett-teller (BET) analysis, zeta-potential, x-ray powder diffraction (XRD), Ultraviolet-visible (UV–Vis) spectroscopy, transmission electron microscopy (TEM), fourier transform infrared (FTIR) spectroscopy, and energy-dispersive system (EDS) spectroscopy. TEM results indicated that Au nanoparticles with the 10&#xa0;nm mean size were covered on the MSNs’ surfaces effectively. The cytotoxicity analysis was evaluated through the MTT assay. Res-templated Au-decorated MSNs indicated low cytotoxicity and acceptable safety even at high concentrations. The results indicate that the green synthesized Res-templated Au-decorated MSNs could be applicable in biomedical in the next future.</p>

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Insights into the Biological Efficacy of Green Synthesized Resveratrol-Templated Mesoporous Silica Nanoparticles Decorated with Gold Nanoparticles

  • 期刊论文

  • 发表日期：

    2025年10月16日

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  • Sareh Mosleh-Shirazi,
  • Milad Abbasi,
  • Hesam Kamyab,
  • Seyed Reza Kasaee,
  • Farzaneh Mohamadpour,
  • Ehsan Vafa,
  • Ahmad Vaez,
  • Ali Feiz,
  • Hengameh Honarkar,
  • Ali Mohammad Amani,
  • Shreeshivadasan Chelliapan

摘要

Mesoporous silica nanoparticles (MSNs) have been recently used in different biomedical applications such as antimicrobial alternatives, drug delivery, and bioimaging. MSNs might be synthesized via green synthesize techniques as a sustainable and environmentally friendly approach, to develop physical properties for nanomedicine applications. In this study, Resveratrol (Res) extract, a polyphenol, was used as the stable and reducing agent for the green synthesis of Res-templated Au-decorated MSNs. Several analytical techniques were used to characterize the samples, like scanning electron microscopy (SEM), brauer-emmett-teller (BET) analysis, zeta-potential, x-ray powder diffraction (XRD), Ultraviolet-visible (UV–Vis) spectroscopy, transmission electron microscopy (TEM), fourier transform infrared (FTIR) spectroscopy, and energy-dispersive system (EDS) spectroscopy. TEM results indicated that Au nanoparticles with the 10 nm mean size were covered on the MSNs’ surfaces effectively. The cytotoxicity analysis was evaluated through the MTT assay. Res-templated Au-decorated MSNs indicated low cytotoxicity and acceptable safety even at high concentrations. The results indicate that the green synthesized Res-templated Au-decorated MSNs could be applicable in biomedical in the next future.