<p>Wound healing remains a significant clinical challenge, particularly in chronic and non-healing wounds where conventional treatments often prove inadequate. Improving bioactivity and biocompatibility presents promising avenues for incorporating smart technology into therapeutic approaches. Such enhancements are critical for addressing limitations associated with wound healing strategies. Traditional therapies often show limitations due to their lack of adaptability to diverse wound types and pathological situations, leading to a higher risk of infection and delayed healing. Nanotechnology offers the potential to revolutionize traditional wound care by utilizing nanomaterials that possess remarkable properties, such as increased surface area, enhanced reactivity, and the ability to be tailored for specific therapeutic purposes. Inorganic-based nanomaterials have recently emerged as promising candidates to revolutionize wound management due to their unique physicochemical properties and therapeutic functionalities. This review explores the latest advancements in metal and metal oxide nanoparticles, such as silver, gold, zinc oxide, titanium dioxide, and cutting-edge materials like MXenes, which exhibit broad-spectrum antimicrobial activity, anti-inflammatory effects, and the ability to stimulate tissue regeneration. Despite these promising developments, challenges such as toxicity and limited biodegradability should be addressed before clinical translation can be fully realized. By critically examining current research and highlighting innovative approaches, this review underscores the transformative potential of inorganic nanomaterials in next-generation wound healing therapies and identifies key opportunities for future exploration.</p> Graphical Abstract <p></p>