<p>Enzyme is an active area of research in the context of nanoscience. Lysozyme is a readily available enzyme with significant antibacterial properties. Lysozyme is widely used to synthesize and stabilize coinage metal nanoclusters, hindering further aggregation to form nanocrystals. We discussed synthesis methods, fate, formation mechanisms, and applications of superatomic coinage metal nanoclusters, passivated with lysozyme. We also reviewed the effect of physicochemical properties and synergistic behaviour regarding such coinage metal nanoclusters, passivated with histidine. The review will hopefully open a new window to generate other enzyme-stabilized, atomically precise, and biocompatible nanoclusters for biomedical as well as environmental science. </p> Graphical Abstract <p></p>