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<p>In this study a hyaluronic Acid (HA) based adapalene (ADP) loaded liposomal formulation was developed for the treatment of acne vulgaris. Conventional ADP topical formulation is related to additional effects such as irritation, redness, hyperpigmentation, photosensitivity, etc. A HA gel base to assimilate these liposomes for targeting skin may further accelerate the healing process as HA itself holds pharmacological activities such as wound healing and anti-inflammatory activity thus contributing in healing acne. These liposomes were prepared with different concentrations of Soy lecithin, cholesterol and Vitamin E TPGS augmented by Design Expert<sup>®</sup>-13 software. The established formulation was extensively evaluated on in vitro, ex vivo and in vivo parameters. In mice, it masked the skin irritation from the drug when compared with the commercial formulation. The findings revealed that the prepared formulation (ADP-LIPO-HA gel) is better than the ADP-LIPO in an inert Carbopol<sup>®</sup> gel and the commercial formulation in acne treatment.</p> Graphical Abstract <p></p>

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Novel Hyaluronic Acid Based Adapalene Nano Vesicular Formulation for Enhanced anti-acne Control: A Sensitivity and Pharmacodynamic Analysis

  • 期刊论文

  • 发表日期：

    2025年8月7日

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  • Maitrayee Ghosh,
  • Debajyoti Roy,
  • Ravi Pratap Singh,
  • Balak Das Kurmi,
  • Amrinder Singh

摘要

In this study a hyaluronic Acid (HA) based adapalene (ADP) loaded liposomal formulation was developed for the treatment of acne vulgaris. Conventional ADP topical formulation is related to additional effects such as irritation, redness, hyperpigmentation, photosensitivity, etc. A HA gel base to assimilate these liposomes for targeting skin may further accelerate the healing process as HA itself holds pharmacological activities such as wound healing and anti-inflammatory activity thus contributing in healing acne. These liposomes were prepared with different concentrations of Soy lecithin, cholesterol and Vitamin E TPGS augmented by Design Expert®-13 software. The established formulation was extensively evaluated on in vitro, ex vivo and in vivo parameters. In mice, it masked the skin irritation from the drug when compared with the commercial formulation. The findings revealed that the prepared formulation (ADP-LIPO-HA gel) is better than the ADP-LIPO in an inert Carbopol® gel and the commercial formulation in acne treatment.

Graphical Abstract