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<p>Essential oil (EO), a promising natural antimicrobial agent, face challenges in therapeutic applications due to volatility and instability. This study presents a coated peppermint oil-zeolite composite (PO@zeolite) with dual-release functionality. Analysis of 14 zeolites revealed that the High Pressure-Ball-1 (HP-B-1) zeolite demonstrated optimal adsorption capabilities of 30.14% maximum loading, attributed to structural parameters including pore topology, surface area (&gt; 800&#xa0;m²/g), and pore volume. Encapsulation through stirring processes achieved uniform EO and polymer distribution within zeolites, as confirmed by SEM and FTIR analyses. Tuning coating thickness enabled adjustable release: higher coating gain leads to more sustained release and less water-responsive burst release. Synergistic bacteriostatic effects between zeolite excipients and EOs enhanced antimicrobial efficacy against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i>, and <i>Candida albicans</i> through adsorption mechanisms. This study demonstrates multifunctional material design concept for multifunctional carriers for economic EO delivery systems.</p>

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Design and Evaluation of Water-Responsive Polymer-Coated Zeolite as a Synergistic Antibacterial Carrier for Essential Oil Delivery

  • 期刊论文

  • 发表日期：

    2025年5月17日

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  • Xinhui Peng,
  • Yanshuang Shi,
  • Shuai Cen,
  • Minyue Jia,
  • Qing Zhou,
  • Weishuo Ren,
  • Bingxuan Li,
  • Guoqing Li,
  • Yueyang Xie,
  • Xingxing Dai,
  • Xinyuan Shi

摘要

Essential oil (EO), a promising natural antimicrobial agent, face challenges in therapeutic applications due to volatility and instability. This study presents a coated peppermint oil-zeolite composite (PO@zeolite) with dual-release functionality. Analysis of 14 zeolites revealed that the High Pressure-Ball-1 (HP-B-1) zeolite demonstrated optimal adsorption capabilities of 30.14% maximum loading, attributed to structural parameters including pore topology, surface area (> 800 m²/g), and pore volume. Encapsulation through stirring processes achieved uniform EO and polymer distribution within zeolites, as confirmed by SEM and FTIR analyses. Tuning coating thickness enabled adjustable release: higher coating gain leads to more sustained release and less water-responsive burst release. Synergistic bacteriostatic effects between zeolite excipients and EOs enhanced antimicrobial efficacy against Escherichia coli, Staphylococcus aureus, and Candida albicans through adsorption mechanisms. This study demonstrates multifunctional material design concept for multifunctional carriers for economic EO delivery systems.