Biological Efficacy Evaluation of Lab Synthesized MgGA Bio-MOF as an Antioxidant Agent and Drug Vehicle

In this work, a magnesium-based biomolecule metal organic framework (MgGA Bio-MOF) has been synthesized using magnesium chloride hexahydrate (MgCl₂.6H₂O) as a metal cation and an edible linker gallic acid (GA, C₆H₂(OH)₃CO₂H) as a organic building unit in water under certain experimental conditions. Initially, MgGA Bio-MOF synthesis has been confirmed through  spectroscopic and microscopic analysis techniques. Afterwards, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay has been performed to know the antioxidant activity of MOF. From the DPPH assay, it has been found that MgGA Bio-MOF possesses 70.4% scavenging activity. To proceed further, the drug release studies have been performed through IBU@MgGA Bio-MOF conjugate using UV- vis spectroscopy In investigation of drug release studies, we have observed 79% IBU released up to 150 min from IBU@MgGA Bio-MOF conjugate at neutral pH. After that, a constant absorbance has been observed, indicating the complete release of IBU. Overall, we found the selected BioMOF has excellent biological utility as an antioxidant agent as well as an anti-inflammatory drug carrier in line of its real-world applications