<p>Experimental vignette methodology (EVM) can serve as a powerful tool for testing causal hypotheses in organizational and applied psychology research. Yet, researchers often lack actionable guidance for navigating the practical decisions inherent in vignette-based study design. To address this, we provide applied methodological recommendations across four critical domains: evaluating research question suitability for EVM, selecting between- versus within-subjects designs, developing ecologically grounded vignettes and manipulations, and safeguarding data integrity. We argue that best practices in EVM are inherently context-dependent and must be evaluated with respect to the specific research question, sample characteristics, and ecological validity of the design rather than applied as universal prescriptions. By offering explicit, decision-oriented guidance supported by illustrative examples from published research, this manuscript aims to strengthen the rigor and credibility of vignette-based research, equip both researchers and peer reviewers with a framework for evaluating EVM studies, and ultimately encourage the broader adoption of well-executed vignette designs in the field.</p>