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<p>Montmorillonite (MMT) is a natural clay mineral and the major component of bentonite, and it possesses an exceptional swelling capacity, a high potential for adsorption, and excellent biocompatibility. Therefore, MMT has been identified as an attractive candidate for pharmaceutical applications in drug nano delivery systems. In recent years, research on MMT has also gained momentum because of its ability to improve the solubility, rate of dissolution, and bioavailability of poor-water-soluble drugs in polymeric nanocomposites. Although much research has been done on the formulation advantages of MMT, critical analysis of their translational progress and industrial uptake remains inadequate. This reviews an in-depth study of the role of MMT as a pharmaceutical excipient in nano drug delivery through a synergy of published work and patent landscape analysis. Patents on MMT-based formulations are sequenced and scrutinized to identify significant players in the industry, therapeutic applications, and emerging patterns of technology. In the comparative assessment of research publications vis-a-vis patents in the decade under review, evolving innovation patterns have of late drawn attention to scalable, multifunctional, clinically relevant MMT nanocomposites. Overall, the review indicates how MMT is gaining importance in pharmaceutical development and what it will provide for the future concerning rational design, regulatory convergence, and commercialization of MMT-embedded polymeric nano drug delivery systems.</p> Graphical Abstract <p></p>

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Montmorillonite in next-generation drug delivery: patent trends, safety insights, and industrial advancements

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月24日

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  • Afzal Haq Asif,
  • B. R. Asha,
  • Samathoti Prasanthi,
  • Prakash Goudanavar,
  • Kalappa Prashantha,
  • K. S. Srikruthi,
  • N. Raghavendra Naveen,
  • Girish Meravanige,
  • Predeepkumar Narayanappa Shiroorka,
  • Krishna Swaroop,
  • Pavan Kumar Pavagada Sreenivasalu,
  • Nagaraja Sreeharsha

摘要

Montmorillonite (MMT) is a natural clay mineral and the major component of bentonite, and it possesses an exceptional swelling capacity, a high potential for adsorption, and excellent biocompatibility. Therefore, MMT has been identified as an attractive candidate for pharmaceutical applications in drug nano delivery systems. In recent years, research on MMT has also gained momentum because of its ability to improve the solubility, rate of dissolution, and bioavailability of poor-water-soluble drugs in polymeric nanocomposites. Although much research has been done on the formulation advantages of MMT, critical analysis of their translational progress and industrial uptake remains inadequate. This reviews an in-depth study of the role of MMT as a pharmaceutical excipient in nano drug delivery through a synergy of published work and patent landscape analysis. Patents on MMT-based formulations are sequenced and scrutinized to identify significant players in the industry, therapeutic applications, and emerging patterns of technology. In the comparative assessment of research publications vis-a-vis patents in the decade under review, evolving innovation patterns have of late drawn attention to scalable, multifunctional, clinically relevant MMT nanocomposites. Overall, the review indicates how MMT is gaining importance in pharmaceutical development and what it will provide for the future concerning rational design, regulatory convergence, and commercialization of MMT-embedded polymeric nano drug delivery systems.

Graphical Abstract