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<p>Thyroid cancer is a significant worldwide health challenge, requiring sophisticated treatment strategies to minimize off-target side effects. In this study, we developed biodegradable polyethylene glycol (PEG)-coated manganese dioxide (MD) nanomaterials, coupled with carminic acid (CA), for thyroid cancer chemo-photodynamic therapy (PDT). The pH-responsive PMD-CA NMs facilitates effective CA release at acidic pH. PMD-CA NMs enhances the efficiency of chemo-PDT through a synergistic reaction. PXRD examination of PMD-CA NMs confirmed a crystal structure. Surface morphology was validated by TEM and SEM analysis, which revealed a spherical shape. The anticancer efficacy of PMD-CA NMs was evaluated against the SW-1736 anaplastic thyroid cancer cells by an MTT assay. Furthermore, it can prevent the proliferation of SW-1736 cells, regardless of light exposure. The apoptosis induced by the PMD-CA NMs in SW-1736 cells was evidenced using calcein AM and PI staining, as well as Annexin V-FITC staining. Further, we demonstrated that PMD-CA NMs increased ROS levels and depolarized mitochondrial membrane potential (MMP), thereby initiating programmed cell death. The results indicate that the responsive PMD-CA NMs system is a promising strategy for thyroid cancer therapy with less cytotoxicity.</p><p></p>

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Fabrication of carminic acid-loaded polymer coated manganese dioxide nanomaterials for apoptosis synergistic chemo/photodynamic therapy for anaplastic thyroid cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月9日

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  • Shao-Jun Cai,
  • Zi-Han Tang,
  • Teng-Hong Liu,
  • Shou-Yi Yan,
  • Meng-Ting Lin,
  • Wen-Xin Zhao,
  • Li-Yong Zhang

摘要

Thyroid cancer is a significant worldwide health challenge, requiring sophisticated treatment strategies to minimize off-target side effects. In this study, we developed biodegradable polyethylene glycol (PEG)-coated manganese dioxide (MD) nanomaterials, coupled with carminic acid (CA), for thyroid cancer chemo-photodynamic therapy (PDT). The pH-responsive PMD-CA NMs facilitates effective CA release at acidic pH. PMD-CA NMs enhances the efficiency of chemo-PDT through a synergistic reaction. PXRD examination of PMD-CA NMs confirmed a crystal structure. Surface morphology was validated by TEM and SEM analysis, which revealed a spherical shape. The anticancer efficacy of PMD-CA NMs was evaluated against the SW-1736 anaplastic thyroid cancer cells by an MTT assay. Furthermore, it can prevent the proliferation of SW-1736 cells, regardless of light exposure. The apoptosis induced by the PMD-CA NMs in SW-1736 cells was evidenced using calcein AM and PI staining, as well as Annexin V-FITC staining. Further, we demonstrated that PMD-CA NMs increased ROS levels and depolarized mitochondrial membrane potential (MMP), thereby initiating programmed cell death. The results indicate that the responsive PMD-CA NMs system is a promising strategy for thyroid cancer therapy with less cytotoxicity.