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<p>Calcium-phosphate cement (CPC), a paste-like artificial bone, is a material form that allows minimally invasive treatment. However, CPC is not infection resistant, which may lead to surgical site infections. We recently developed a paste-like organic/inorganic hybrid artificial bone that is compatible with the bone remodeling cycle. In this study, we added silver-loaded tricalcium phosphate, which has antibacterial properties, to the hybrid CPC and fabricated a prototype “antibacterial CPC”. Antibacterial and non-antibacterial CPCs were implanted into a rabbit jaw defect model in which infection could occur, and the in vivo responses were compared. In cement specimens retrieved from rabbit jaws, residual material was observed with the non-antibacterial CPC, whereas with the antibacterial CPC, almost all of the material was resorbed and replaced with host bone. These results suggest that placement of antibacterial CPC in a rabbit jaw bone defect model susceptible to bacterial infection promotes material resorption and bone formation. The antibacterial CPC developed in this study is thus a novel paste artificial bone exhibiting good bioresorption and osteogenic potential in biological hard tissues.</p><p></p>

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In vivo responses of β-tricalcium phosphate–based paste-like artificial bone with antibacterial properties under potentially infectious conditions using a rabbit model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月30日

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  • H. Miyashita,
  • Y. Kamaya,
  • K. Suzuki,
  • S. Kato,
  • S. Morikawa,
  • T. Soma,
  • M. Nasu,
  • K. Munakata,
  • T. Nakagawa,
  • M. Aizawa

摘要

Calcium-phosphate cement (CPC), a paste-like artificial bone, is a material form that allows minimally invasive treatment. However, CPC is not infection resistant, which may lead to surgical site infections. We recently developed a paste-like organic/inorganic hybrid artificial bone that is compatible with the bone remodeling cycle. In this study, we added silver-loaded tricalcium phosphate, which has antibacterial properties, to the hybrid CPC and fabricated a prototype “antibacterial CPC”. Antibacterial and non-antibacterial CPCs were implanted into a rabbit jaw defect model in which infection could occur, and the in vivo responses were compared. In cement specimens retrieved from rabbit jaws, residual material was observed with the non-antibacterial CPC, whereas with the antibacterial CPC, almost all of the material was resorbed and replaced with host bone. These results suggest that placement of antibacterial CPC in a rabbit jaw bone defect model susceptible to bacterial infection promotes material resorption and bone formation. The antibacterial CPC developed in this study is thus a novel paste artificial bone exhibiting good bioresorption and osteogenic potential in biological hard tissues.