<p>Derivatives of quinazolin-4(1H)-ones have shown considerable promise for managing a range of disorders, particularly cardiovascular conditions due to their blood-pressure-lowering properties. Consequently, preparation of these heterocyclic structures holds critical importance. To efficiently produce these compounds, a novel Fe₃O₄/NiFe₂O₄/CeO₂ photocatalyst has been developed that facilitates synthesis of these important pharmaceutical compounds. This photocatalyst offers advantages such as enhanced catalytic activity and magnetic recoverability, which improves the overall yield and sustainability of the synthetic process. The photocatalytic reactions performed under the irradiation of a sun simulator (I, 1000 W.m⁻²). This setup mimics natural sunlight by providing a broad spectrum of light, which is essential for simulating real-world conditions and evaluating performance of the photocatalyst under visible light. Techniques for characterization, including FE-SEM, FT-IR, TEM, XPS, UV-VIS, VSM, EDS, and XRD are achieved for identifying the photocatalyst. Optimization studies demonstrated that the reactions proceed efficiently under aerobic condition, yielding excellent results in solvent free conditions. These experiments achieved using 2-aminobenzamide and aromatic aldehydes with 15&#xa0;mg of Fe₃O₄/NiFe₂O₄/CeO₂ photocatalyst under solvent-free for 15&#xa0;min. Additionally, the photocatalyst reusability and stability were evaluated, confirming its practical utility and consistent performance.</p>