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<p>In this study, a mixed-phase nickel/iron-layered double hydroxide (NiFe-LDH) was synthesized via a hydrothermal method and employed as an electrochemical interface for the sensitive and selective detection of dopamine (DA). The structural nature of LDHs, characterized by positively charged layers balanced by intercalated anions, facilitates strong electrostatic interactions with dopamine. These interactions enhance the diffusion of DA toward the electrode surface. Moreover, the NiFe-LDH electrode significantly increases the electroactive surface area, thereby lowering the oxidation overpotential for DA and enhancing the sensor’s analytical performance. The modified electrode demonstrated two distinct linear response ranges for DA (50 to 70&#xa0;nM and 100 to 800&#xa0;nM) and achieved a detection limit as low as 0.5&#xa0;nM. Application of the developed sensor in pharmaceutical formulations yielded high recovery rates, confirming its practical applications. The promising results highlight the potential of mixed-phase NiFe-LDH materials in fabricating reliable electrochemical devices for dopamine monitoring in pharmaceutical and clinical settings.</p>

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NiFe layer double hydroxide-modified glassy carbon electrode as electrochemical interface for dopamine sensing

  • 期刊论文

  • 发表日期：

    2026年2月20日

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  • V. S. Nanjundappa,
  • K. Suresh Kumar,
  • T. Ramakrishnappa,
  • K. S. Manjunatha Kumara,
  • D. H. Nagaraju,
  • H. R. Prakash,
  • S. S. Ramesha,
  • B. M. Praveen

摘要

In this study, a mixed-phase nickel/iron-layered double hydroxide (NiFe-LDH) was synthesized via a hydrothermal method and employed as an electrochemical interface for the sensitive and selective detection of dopamine (DA). The structural nature of LDHs, characterized by positively charged layers balanced by intercalated anions, facilitates strong electrostatic interactions with dopamine. These interactions enhance the diffusion of DA toward the electrode surface. Moreover, the NiFe-LDH electrode significantly increases the electroactive surface area, thereby lowering the oxidation overpotential for DA and enhancing the sensor’s analytical performance. The modified electrode demonstrated two distinct linear response ranges for DA (50 to 70 nM and 100 to 800 nM) and achieved a detection limit as low as 0.5 nM. Application of the developed sensor in pharmaceutical formulations yielded high recovery rates, confirming its practical applications. The promising results highlight the potential of mixed-phase NiFe-LDH materials in fabricating reliable electrochemical devices for dopamine monitoring in pharmaceutical and clinical settings.