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<p>The purpose of this research is to develop a graphene-based self-assembly method for the easy electrochemical detection of albumin, urea, and ascorbic acid in a nanocomposite (SnO<sub>2</sub>-G-ZnO). Excessive ingestion of these biomolecules negatively impacts the kidney, liver, and digestive tract. However, the current detection methods for these biomolecules are expensive, time-consuming, and require highly skilled operators. Therefore, we aim to develop an easily detectable method for these biomolecules with good sensitivity. The SnO<sub>2</sub>-G-ZnO nanocomposite has unique properties, such as high sensitivity, excellent electron mobility, selectivity, low-cost, and improved surface attributes, which make it a promising material for sensitive and reliable biosensors. Moreover, these active materials have included porosity properties that enhance immobilized of the target materials with electrode. The synthesized materials, prepared using the self-assembly method, were evaluated using electrochemical performance instruments, electron attitude-regulating spectroscopy, and surface morphology approaches. Due to the biocompatibility characteristics, SnO<sub>2</sub> and ZnO can easily interact with the functional groups these biomarkers, namely, (–NH<sub>2</sub>), (–COOH), (C=O), and (–OH). Under ideal conditions, the sensor is able to detect biomolecules in electrical tests ranging from 0.05 to 0.25&#xa0;μM, demonstrating excellent sensitivity. This analysis confirms the accurate detection of these biomolecules.</p>

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Ternary type active material-based nanocomposite for high selective sensing performance with various biomolecules

  • 期刊论文

  • 发表日期：

    2025年11月4日

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  • Latiful Kabir,
  • Young Jun Joo,
  • Kwang Youn Cho,
  • Won-Chun Oh

摘要

The purpose of this research is to develop a graphene-based self-assembly method for the easy electrochemical detection of albumin, urea, and ascorbic acid in a nanocomposite (SnO2-G-ZnO). Excessive ingestion of these biomolecules negatively impacts the kidney, liver, and digestive tract. However, the current detection methods for these biomolecules are expensive, time-consuming, and require highly skilled operators. Therefore, we aim to develop an easily detectable method for these biomolecules with good sensitivity. The SnO2-G-ZnO nanocomposite has unique properties, such as high sensitivity, excellent electron mobility, selectivity, low-cost, and improved surface attributes, which make it a promising material for sensitive and reliable biosensors. Moreover, these active materials have included porosity properties that enhance immobilized of the target materials with electrode. The synthesized materials, prepared using the self-assembly method, were evaluated using electrochemical performance instruments, electron attitude-regulating spectroscopy, and surface morphology approaches. Due to the biocompatibility characteristics, SnO2 and ZnO can easily interact with the functional groups these biomarkers, namely, (–NH2), (–COOH), (C=O), and (–OH). Under ideal conditions, the sensor is able to detect biomolecules in electrical tests ranging from 0.05 to 0.25 μM, demonstrating excellent sensitivity. This analysis confirms the accurate detection of these biomolecules.