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<p>The development of high-performance electrochemical sensors for the selective detection of dopamine (DA) is crucial for neurological diagnostics and biomedical applications. In this study, we report a reduced graphene oxide–copper oxide (rGO–CuO) nanocomposite synthesized via a hydrothermal method. The structural and morphological characteristics of the synthesized materials were investigated using High Resolution&#xa0;Transmission Electron Microscopy (HR-TEM), Energy-Dispersive X-ray Spectroscopy (EDX), X-ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FT-IR), Zeta potential was measured using a particle size analyzer. The spectroscopic analyses confirmed the successful incorporation of CuO nanostructures onto the rGO sheet. The rGO–CuO modified glassy carbon electrode (GCE) exhibited enhanced electrocatalytic activity toward dopamine oxidation, as verified by cyclic voltammetry (CV)&#xa0;and differential pulse voltammerty (DPV) studies, owing to the synergistic effects of rGO’s high conductivity and CuO’s catalytic properties. The rGO–CuO nanocomposite demonstrated a linear current response for DA over the concentration range of 0.0065–0.081&#xa0;nM, with an ultra-low detection limit of 5.03&#xa0;nM. The sensor material exhibited high selectivity for DA even in the presence of common interfering biomolecules such as uric acid, glucose, L-alanine, leucine, and lysine. Furthermore, the nanocomposite was successfully applied for DA detection in human urine samples, confirming its practical applicability for real sample analysis. This study presents a simple and scalable approach for synthesizing rGO–CuO nanocomposites and highlights their potential for ultrasensitive and selective neurotransmitter detection.</p>

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Engineering rGO–CuO nanocomposites for enhanced electrochemical detection of dopamine

  • 期刊论文

  • 发表日期：

    2025年8月22日

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  • Anil A. Powar,
  • Anita K. Tawade,
  • Kiran Kumar K. Sharma,
  • Dattatray J. Sathe,
  • Vishnu Dev Gupta,
  • Shivaji N. Tayade

摘要

The development of high-performance electrochemical sensors for the selective detection of dopamine (DA) is crucial for neurological diagnostics and biomedical applications. In this study, we report a reduced graphene oxide–copper oxide (rGO–CuO) nanocomposite synthesized via a hydrothermal method. The structural and morphological characteristics of the synthesized materials were investigated using High Resolution Transmission Electron Microscopy (HR-TEM), Energy-Dispersive X-ray Spectroscopy (EDX), X-ray Diffraction (XRD), and Fourier Transform Infrared Spectroscopy (FT-IR), Zeta potential was measured using a particle size analyzer. The spectroscopic analyses confirmed the successful incorporation of CuO nanostructures onto the rGO sheet. The rGO–CuO modified glassy carbon electrode (GCE) exhibited enhanced electrocatalytic activity toward dopamine oxidation, as verified by cyclic voltammetry (CV) and differential pulse voltammerty (DPV) studies, owing to the synergistic effects of rGO’s high conductivity and CuO’s catalytic properties. The rGO–CuO nanocomposite demonstrated a linear current response for DA over the concentration range of 0.0065–0.081 nM, with an ultra-low detection limit of 5.03 nM. The sensor material exhibited high selectivity for DA even in the presence of common interfering biomolecules such as uric acid, glucose, L-alanine, leucine, and lysine. Furthermore, the nanocomposite was successfully applied for DA detection in human urine samples, confirming its practical applicability for real sample analysis. This study presents a simple and scalable approach for synthesizing rGO–CuO nanocomposites and highlights their potential for ultrasensitive and selective neurotransmitter detection.