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<p>Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) detection is crucial in biological, environmental, and industrial contexts, serving as a biomarker for oxidative stress, an enzymatic reaction product, and a common oxidizing agent. Metal–organic frameworks (MOFs) have emerged as promising candidates for electrochemical sensors due to their unique structural properties and tunable characteristics. This study reports the synthesis and characterization of a cobalt metal–organic framework (Co-MOF) as an electrochemical platform for H<sub>2</sub>O<sub>2</sub> detection. The Co-MOF was synthesized via a two-step procedure: formation of the organic ligand (H<sub>2</sub>L) followed by coordination with cobalt centers. Electrochemical characterization revealed excellent electron transfer properties with a surface-controlled process (b = 0.992) and diffusion-controlled kinetics. The sensor exhibited a high sensitivity of 91.75 μA/μM/cm<sup>2</sup> towards H<sub>2</sub>O<sub>2</sub>, with a linear response range of 2–1000&#xa0;μM and a detection limit of 0.25&#xa0;μM (S/N = 3). The enhanced sensing performance can be attributed to synergistic mechanisms: rapid electron transfer via Co centers, facilitated mass transport through the porous structure, and efficient catalytic decomposition of H<sub>2</sub>O<sub>2</sub>. Electrochemical impedance spectroscopy indicated a low charge transfer resistance (~ 200 Ω), suggesting favorable interfacial properties. This study establishes a foundation for developing high-performance MOF-based electrochemical sensors for H<sub>2</sub>O<sub>2</sub> detection in biological and environmental applications, with potential utility in clinical diagnostics, environmental monitoring, and industrial process control.</p>

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Design and development of Co-MOF as an efficient electrochemical platform for H2O2 sensing

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • Hidayath Mirza,
  • Abdoh Jabbari,
  • Muhammad Shahid Rashid,
  • Ali Asghar,
  • Shahzad Ahmed,
  • Haneef Khan,
  • Nishat Sultana,
  • Syed Kashif Ali,
  • Mohd Imran

摘要

Hydrogen peroxide (H2O2) detection is crucial in biological, environmental, and industrial contexts, serving as a biomarker for oxidative stress, an enzymatic reaction product, and a common oxidizing agent. Metal–organic frameworks (MOFs) have emerged as promising candidates for electrochemical sensors due to their unique structural properties and tunable characteristics. This study reports the synthesis and characterization of a cobalt metal–organic framework (Co-MOF) as an electrochemical platform for H2O2 detection. The Co-MOF was synthesized via a two-step procedure: formation of the organic ligand (H2L) followed by coordination with cobalt centers. Electrochemical characterization revealed excellent electron transfer properties with a surface-controlled process (b = 0.992) and diffusion-controlled kinetics. The sensor exhibited a high sensitivity of 91.75 μA/μM/cm2 towards H2O2, with a linear response range of 2–1000 μM and a detection limit of 0.25 μM (S/N = 3). The enhanced sensing performance can be attributed to synergistic mechanisms: rapid electron transfer via Co centers, facilitated mass transport through the porous structure, and efficient catalytic decomposition of H2O2. Electrochemical impedance spectroscopy indicated a low charge transfer resistance (~ 200 Ω), suggesting favorable interfacial properties. This study establishes a foundation for developing high-performance MOF-based electrochemical sensors for H2O2 detection in biological and environmental applications, with potential utility in clinical diagnostics, environmental monitoring, and industrial process control.