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<p>Dopamine (DA), a neurotransmitter of the catecholamine class that has a range of functions in the mammalian central nervous system, is used to diagnose neurodegenerative diseases like schizophrenia, Parkinson’s illness, and Alzheimer’s disease. Therefore, it is an important biomarker to assess these diseases by measuring with low-cost, sensitive, and selective methods. In this research, we provided these advantages by engineering a molecularly imprinted impedimetric sensor to detect dopamine. The surface was modified with boronic acid residues and aminophenylboronic (APBA) acid and pyrrole-3-carboxylic (PyCOOH) acid were used as functional monomers around dopamine. Detection of dopamine was carried out by electrochemical impedance spectroscopy (EIS). According to the calibration curve between 100 and 600&#xa0;pM (<i>R</i><sup>2</sup> = 0.9517), the sensor system’s performance parameters were established, and the limit of detection (LOD) and limit of quantification (LOQ) were discovered to be 30.34 and 95.82&#xa0;pM, respectivey.</p>

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A novel molecularly imprinted polymers on self-assembly monolayer gold electrode impedimetric detection of dopamine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月9日

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  • Hilmiye Deniz Ertuğrul Uygun,
  • M. Nalan Demir

摘要

Dopamine (DA), a neurotransmitter of the catecholamine class that has a range of functions in the mammalian central nervous system, is used to diagnose neurodegenerative diseases like schizophrenia, Parkinson’s illness, and Alzheimer’s disease. Therefore, it is an important biomarker to assess these diseases by measuring with low-cost, sensitive, and selective methods. In this research, we provided these advantages by engineering a molecularly imprinted impedimetric sensor to detect dopamine. The surface was modified with boronic acid residues and aminophenylboronic (APBA) acid and pyrrole-3-carboxylic (PyCOOH) acid were used as functional monomers around dopamine. Detection of dopamine was carried out by electrochemical impedance spectroscopy (EIS). According to the calibration curve between 100 and 600 pM (R2 = 0.9517), the sensor system’s performance parameters were established, and the limit of detection (LOD) and limit of quantification (LOQ) were discovered to be 30.34 and 95.82 pM, respectivey.