In this study, the magnetic and magneto-transport properties of polycrystalline \(\hbox {Sm}_{0.50}\hbox {Sr}_{0.50}\hbox {MnO}_3\) have been investigated. The presence of short-range magnetic order plays a crucial role in influencing electron transport, making it a promising pathway for tuning magnetoresistive properties for specific applications. This research focuses on the effects of magnetic nanoclusters on spin-dependent scattering and their impact on magneto-transport and magnetocaloric properties in polycrystalline \(\hbox {Sm}_{0.50}\hbox {Sr}_{0.50}\hbox {MnO}_3\) . Experimental results reveal a significant magnetocaloric effect and notable magnetoresistance within the liquid nitrogen temperature range. At 100 K, the magnetoresistance reaches approximately 70% under an external magnetic field of 20 kOe. The magnetocaloric entropy change is calculated to be 3.5 J/kg-K for a 70 kOe magnetic field, with the entropy change curve exhibiting a broadened peak, leading to a substantial Relative Cooling Power (RCP). These findings enhance our understanding of the material’s behavior and highlight its potential for various technological applications.