Scholarlink

<p>Although β-TCP bioceramics exhibits excellent biocompatibility and bioactivity, their inherent brittleness significantly restricts their broader applications. This research aimed to enhance the mechanical properties and biocompatibility of β-TCP by incorporating ZnO, SrO, and Akermanite (AK) as functional additives. The fabrication process utilized digital light processing (DLP) technology to create β-TCP/ZnO/SrO/AK ceramic green bodies, which were subsequently subjected to high-temperature debinding and sintering to obtain the final ceramic scaffolds. The composite exhibited the most favourable overall performance and was selected for further degradation behaviour and biocompatibility evaluation. The effects of ZnO/SrO/AK ratios on the mechanical strength of the composites were systematically investigated. For the tested compositions, the β-TCP/ZnO0.5/SrO2/AK2 (TZSA) samples demonstrated superior mechanical properties. This optimization made the compressive strength of the TZSA scaffolds increase by 35%, compared to the original β-TCP scaffolds. Additionally, the TZSA scaffolds exhibited a more favourable pH environment, enhanced apatite mineralization ability, and sustained release of Si<sup>4+</sup>, Mg<sup>2+</sup>, Sr<sup>2+</sup>, and Zn<sup>2+</sup> ions from the scaffolds. The evaluation in vitro demonstrated that the TZSA scaffolds significantly promoted cell proliferation and alkaline phosphatase (ALP) activity, while also upregulated osteogenic genes, including ALP, osteocalcin (OCN), Runt-related transcription factor 2 (Runx2), and osteopontin (OPN). These findings highlight the potential of TZSA scaffolds as a promising solution for bone repair applications. The synergistic incorporation of ZnO/SrO/AK into β-TCP scaffolds not only enhances mechanical and biological properties but also significantly improves the physicochemical and osteogenic performance of the porous scaffolds. The optimized TZSA scaffolds with enhanced compressive strength, bioactivity, and osteogenesis-related gene expression represent a promising strategy to widen bone repair applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bioactive β-tricalcium phosphate (β-TCP)/ZnO/SrO/akermanite scaffolds with TPMS-gyroid structure by digital light processing for bone regeneration

  • 期刊论文

  • 发表日期：

    2026年7月23日

查看全文
  • Shan Wei,
  • Junqi Chai,
  • Xinxin Zhang,
  • Kun Wang,
  • Xiang Li,
  • Zhengyu Wang,
  • Yifan Gu,
  • Assia Faik,
  • Chengtao Xu,
  • He Liu

摘要

Although β-TCP bioceramics exhibits excellent biocompatibility and bioactivity, their inherent brittleness significantly restricts their broader applications. This research aimed to enhance the mechanical properties and biocompatibility of β-TCP by incorporating ZnO, SrO, and Akermanite (AK) as functional additives. The fabrication process utilized digital light processing (DLP) technology to create β-TCP/ZnO/SrO/AK ceramic green bodies, which were subsequently subjected to high-temperature debinding and sintering to obtain the final ceramic scaffolds. The composite exhibited the most favourable overall performance and was selected for further degradation behaviour and biocompatibility evaluation. The effects of ZnO/SrO/AK ratios on the mechanical strength of the composites were systematically investigated. For the tested compositions, the β-TCP/ZnO0.5/SrO2/AK2 (TZSA) samples demonstrated superior mechanical properties. This optimization made the compressive strength of the TZSA scaffolds increase by 35%, compared to the original β-TCP scaffolds. Additionally, the TZSA scaffolds exhibited a more favourable pH environment, enhanced apatite mineralization ability, and sustained release of Si4+, Mg2+, Sr2+, and Zn2+ ions from the scaffolds. The evaluation in vitro demonstrated that the TZSA scaffolds significantly promoted cell proliferation and alkaline phosphatase (ALP) activity, while also upregulated osteogenic genes, including ALP, osteocalcin (OCN), Runt-related transcription factor 2 (Runx2), and osteopontin (OPN). These findings highlight the potential of TZSA scaffolds as a promising solution for bone repair applications. The synergistic incorporation of ZnO/SrO/AK into β-TCP scaffolds not only enhances mechanical and biological properties but also significantly improves the physicochemical and osteogenic performance of the porous scaffolds. The optimized TZSA scaffolds with enhanced compressive strength, bioactivity, and osteogenesis-related gene expression represent a promising strategy to widen bone repair applications.