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<p>Nitrogen- and phosphorus-doped carbon dots (N,P-CDs) were synthesized as a dual-mode fluorescence and room-temperature phosphorescence (RTP) probe for selective determination of omeprazole. The nanomaterial exhibited intense blue fluorescence (lifetime 4.32&#xa0;ns) and long-lived green phosphorescence (lifetime 23.31&#xa0;ms) with visible solid-state afterglow. Omeprazole addition quenched both emission modes. Time-resolved analysis revealed reduced fluorescence and phosphorescence lifetimes (1.23&#xa0;ns and 2.13&#xa0;ms, respectively), indicating dynamic quenching, supported by UV–Vis, FTIR, and DSC. The detection limits were 2.04&#xa0;μM for fluorescence and 2.88&#xa0;μM for phosphorescence. Compared with single fluorescence or phosphorescence detection, this dual-mode sensing approach provides complementary signal outputs that enable self-calibration, effectively reduce false-positive or false-negative risks, and minimize interferences from environmental or instrumental fluctuations, thereby significantly enhancing the analytical reliability and accuracy. The probe showed high selectivity against amino acids, vitamins, and coexisting drugs. Recoveries from commercial capsules ranged 97.85–101.22% (RSD &lt; 1.05%). Thus, this dual-mode carbon dots (CDs) probe offers a sensitive, reliable method for omeprazole determination in pharmaceuticals.</p>

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Dual-mode fluorescence-phosphorescence carbon dots for determination of omeprazole in pharmaceutical formulations

  • 期刊论文

  • 发表日期：

    2026年7月1日

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  • Abdellateif Okkod,
  • Ruijun Zou,
  • Sen Zhou,
  • Xiaoming Yang

摘要

Nitrogen- and phosphorus-doped carbon dots (N,P-CDs) were synthesized as a dual-mode fluorescence and room-temperature phosphorescence (RTP) probe for selective determination of omeprazole. The nanomaterial exhibited intense blue fluorescence (lifetime 4.32 ns) and long-lived green phosphorescence (lifetime 23.31 ms) with visible solid-state afterglow. Omeprazole addition quenched both emission modes. Time-resolved analysis revealed reduced fluorescence and phosphorescence lifetimes (1.23 ns and 2.13 ms, respectively), indicating dynamic quenching, supported by UV–Vis, FTIR, and DSC. The detection limits were 2.04 μM for fluorescence and 2.88 μM for phosphorescence. Compared with single fluorescence or phosphorescence detection, this dual-mode sensing approach provides complementary signal outputs that enable self-calibration, effectively reduce false-positive or false-negative risks, and minimize interferences from environmental or instrumental fluctuations, thereby significantly enhancing the analytical reliability and accuracy. The probe showed high selectivity against amino acids, vitamins, and coexisting drugs. Recoveries from commercial capsules ranged 97.85–101.22% (RSD < 1.05%). Thus, this dual-mode carbon dots (CDs) probe offers a sensitive, reliable method for omeprazole determination in pharmaceuticals.