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<p>This study aimed to evaluate the effect of chitosan (CHI) concentration (0.010, 0.015, and 0.020&#xa0;g/g) on the functionalization of Al<sub>2</sub>O<sub>3</sub>/ZrO<sub>2</sub> (AZ5%) ceramic scaffolds produced by gelcasting, focusing on polymer penetration, surface deposition, surface wettability and fluid absorption behavior. Scaffolds were coated by dip-coating and characterized by XRD, FTIR, SEM, confocal microscopy, contact angle, and swelling tests in simulated body fluid (SBF). Lower CHI concentrations promoted greater polymer infiltration into scaffold pores due to reduced viscosity, whereas higher concentrations favored surface deposition. Scaffolds coated with 0.010&#xa0;g/g CHI exhibited faster SBF absorption and higher swelling capacity than those with 0.020&#xa0;g/g. Overall, CHI concentration critically influences coating efficiency and scaffold physicochemical properties. Lower CHI concentrations optimized pore infiltration and hydrophilicity, parameters commonly associated in the literature with mass transport and material–fluid interactions relevant to bone tissue engineering applications.</p> Graphical abstract <p></p>

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Chitosan-functionalized Al2O3/ZrO2 ceramic scaffolds: effect of polymer concentration

  • 期刊论文

  • 发表日期：

    2026年7月4日

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  • Thaís de Cássia Naitzel,
  • Julieta A. Ferreira,
  • Fábulo R. Monteiro,
  • Carla A. Monaco Lourenço,
  • Cristiana M. P. Yoshida,
  • Fernanda M. Vanin,
  • Eliria M. J. A. Pallone,
  • Rosemary A. Carvalho

摘要

This study aimed to evaluate the effect of chitosan (CHI) concentration (0.010, 0.015, and 0.020 g/g) on the functionalization of Al2O3/ZrO2 (AZ5%) ceramic scaffolds produced by gelcasting, focusing on polymer penetration, surface deposition, surface wettability and fluid absorption behavior. Scaffolds were coated by dip-coating and characterized by XRD, FTIR, SEM, confocal microscopy, contact angle, and swelling tests in simulated body fluid (SBF). Lower CHI concentrations promoted greater polymer infiltration into scaffold pores due to reduced viscosity, whereas higher concentrations favored surface deposition. Scaffolds coated with 0.010 g/g CHI exhibited faster SBF absorption and higher swelling capacity than those with 0.020 g/g. Overall, CHI concentration critically influences coating efficiency and scaffold physicochemical properties. Lower CHI concentrations optimized pore infiltration and hydrophilicity, parameters commonly associated in the literature with mass transport and material–fluid interactions relevant to bone tissue engineering applications.

Graphical abstract