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<p>Metal and metal oxide nanostructures are promising candidates for non-enzymatic glucose sensing owing to their high catalytic activity, large surface area, and excellent electrochemical stability. In this study, a binder-free electrocatalytic platform based on a three-dimensional copper foam scaffold decorated with Ni(OH)<sub>2</sub> and Co(OH)<sub>2</sub> nanoparticles anchored on copper oxide nanosheet arrays (CuONSA) is reported. The hierarchical Ni(OH)<sub>2</sub>/Co(OH)<sub>2</sub>/CuONSA/CF electrode was synthesized through a simple wet-chemical oxidation process followed by thermal annealing and electrodeposition and comparative studies among different Ni/Co compositions were systematically carried out to investigate their influence on the electrochemical glucose sensing performance. The vertically aligned CuO nanosheet arrays uniformly cover the conductive copper foam substrate, forming a porous interconnected network with abundant exposed active sites and efficient ion-diffusion channels. In particular, the synergistic interaction between Ni(OH)<sub>2</sub> nanoparticles and the conductive CuO nanosheet arrays significantly enhances charge-transfer kinetics, improves utilization of electroactive Ni<sup>2+</sup>/Ni<sup>3+</sup> redox sites, and facilitates rapid glucose oxidation. Simultaneously, the three-dimensional copper foam framework provides continuous electron-transport pathways and efficient electrolyte accessibility, thereby suppressing surface fouling and improving electrochemical stability. Electrochemical evaluation demonstrates that the NC10/CuONSA/CF electrode exhibits superior glucose sensing performance with a dual linear response range of 0.001&#xa0;mM–0.43&#xa0;mM and 4.0&#xa0;mM–8.6&#xa0;mM, along with high sensitivities of 21509.46 and 238.87&#xa0;µA mM<sup>−1</sup>&#xa0;cm<sup>−2</sup> in low and high concentration regions, respectively, and low detection limits of 4.71 and 424.63&#xa0;µM. Furthermore, the electrode shows excellent selectivity, reproducibility, and long-term stability, demonstrating strong potential for practical non-enzymatic glucose sensing applications.</p> Graphical abstract <p></p>

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Comparative study of Ni(OH)2/Co(OH)2 composition on CuO nanosheet arrays for ultrasensitive, wide-range, and hyperglycemic-level non-enzymatic glucose sensing

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • S. Karunakaran,
  • Shinichi Mizuno,
  • A. Thameemul Ansari,
  • J. Archana,
  • M. Navaneethan,
  • S. Harish,
  • Hiroko Kominami,
  • Atsushi Nakamura

摘要

Metal and metal oxide nanostructures are promising candidates for non-enzymatic glucose sensing owing to their high catalytic activity, large surface area, and excellent electrochemical stability. In this study, a binder-free electrocatalytic platform based on a three-dimensional copper foam scaffold decorated with Ni(OH)2 and Co(OH)2 nanoparticles anchored on copper oxide nanosheet arrays (CuONSA) is reported. The hierarchical Ni(OH)2/Co(OH)2/CuONSA/CF electrode was synthesized through a simple wet-chemical oxidation process followed by thermal annealing and electrodeposition and comparative studies among different Ni/Co compositions were systematically carried out to investigate their influence on the electrochemical glucose sensing performance. The vertically aligned CuO nanosheet arrays uniformly cover the conductive copper foam substrate, forming a porous interconnected network with abundant exposed active sites and efficient ion-diffusion channels. In particular, the synergistic interaction between Ni(OH)2 nanoparticles and the conductive CuO nanosheet arrays significantly enhances charge-transfer kinetics, improves utilization of electroactive Ni2+/Ni3+ redox sites, and facilitates rapid glucose oxidation. Simultaneously, the three-dimensional copper foam framework provides continuous electron-transport pathways and efficient electrolyte accessibility, thereby suppressing surface fouling and improving electrochemical stability. Electrochemical evaluation demonstrates that the NC10/CuONSA/CF electrode exhibits superior glucose sensing performance with a dual linear response range of 0.001 mM–0.43 mM and 4.0 mM–8.6 mM, along with high sensitivities of 21509.46 and 238.87 µA mM−1 cm−2 in low and high concentration regions, respectively, and low detection limits of 4.71 and 424.63 µM. Furthermore, the electrode shows excellent selectivity, reproducibility, and long-term stability, demonstrating strong potential for practical non-enzymatic glucose sensing applications.

Graphical abstract