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<p>In this study, the effect of post-deposition heat treatment on the performance of chitosan/Zn-doped hydroxyapatite (HAp) composite coatings for bioresorbable magnesium alloys is studied. The coatings were manufactured with the aid of dip coating and were heat-treated at 120&#xa0;°C, 240&#xa0;°C, and 360&#xa0;°C. The relationship between surface morphological evolution, corrosion resistance and cell activity were analyzed using a combination of experimental characterization and computational simulations. The changes in the microstructure, scale thickness, and surface morphology were characterized using optical microscopy and scanning electron microscopy. X-ray diffraction analysis also showed increased crystallinity and phase purity of HAp with increasing temperature. Electrochemical impedance spectroscopy and potentiodynamic polarization results confirmed that the coating treated at 240&#xa0;°C exhibited the highest corrosion resistance, with an 80.8% reduction in <i>I</i><sub>corr</sub> compared to the as-deposited sample. This improvement is attributed to the optimal balance between polymer consolidation and ceramic particle sintering achieved at this temperature. In vitro biocompatibility assessments using the MTT assay and DAPI staining further indicated superior performance for the 240&#xa0;°C-treated sample, demonstrating over 110% cell viability and approximately 188 attached cells, which is consistent with its improved surface morphology. In addition, finite element simulations enabled a clearer understanding of the influence of surface stiffness and texture on the mechanostimulation of adherent cells. This study demonstrates the pivotal role of post-deposition heat treatment in modulating the microstructure, corrosion resistance, and bioactivity of chitosan/Zn-HAp coatings, which offers significant implications for advanced surface modification design on biodegradable Mg implants.</p>

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Influence of post-deposition heat treatment on the performance of chitosan/Zn-doped hydroxyapatite composite coatings for bioresorbable magnesium alloys: modeling and experimental approach

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Binod Barai,
  • Abhisek Gupta,
  • Srijani Dey,
  • Ananya Barui,
  • Amit Roy Chowdhury,
  • Subhasish Sarkar,
  • Buddhadeb Oraon,
  • Tapendu Mandal

摘要

In this study, the effect of post-deposition heat treatment on the performance of chitosan/Zn-doped hydroxyapatite (HAp) composite coatings for bioresorbable magnesium alloys is studied. The coatings were manufactured with the aid of dip coating and were heat-treated at 120 °C, 240 °C, and 360 °C. The relationship between surface morphological evolution, corrosion resistance and cell activity were analyzed using a combination of experimental characterization and computational simulations. The changes in the microstructure, scale thickness, and surface morphology were characterized using optical microscopy and scanning electron microscopy. X-ray diffraction analysis also showed increased crystallinity and phase purity of HAp with increasing temperature. Electrochemical impedance spectroscopy and potentiodynamic polarization results confirmed that the coating treated at 240 °C exhibited the highest corrosion resistance, with an 80.8% reduction in Icorr compared to the as-deposited sample. This improvement is attributed to the optimal balance between polymer consolidation and ceramic particle sintering achieved at this temperature. In vitro biocompatibility assessments using the MTT assay and DAPI staining further indicated superior performance for the 240 °C-treated sample, demonstrating over 110% cell viability and approximately 188 attached cells, which is consistent with its improved surface morphology. In addition, finite element simulations enabled a clearer understanding of the influence of surface stiffness and texture on the mechanostimulation of adherent cells. This study demonstrates the pivotal role of post-deposition heat treatment in modulating the microstructure, corrosion resistance, and bioactivity of chitosan/Zn-HAp coatings, which offers significant implications for advanced surface modification design on biodegradable Mg implants.