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<p>In this study, we developed a dual-stimuli-responsive drug delivery system based on TiO₂ nanotube arrays (TNTs) modified with zeolitic imidazolate framework-8 (ZIF-8) and copper sulfide nanoparticles (CuS) for improved antibacterial efficacy and osseointegration. Vancomycin and CuS were co-loaded into the TNTs via a one-pot synthesis approach, and ZIF-8 served as both a high-capacity drug reservoir and a pH-responsive gatekeeper. The system exhibited rapid and controlled drug release under near-infrared (NIR, 808&#xa0;nm) irradiation and acidic conditions, mimicking post-surgical infection sites. The CuS nanoparticles enhanced photothermal conversion efficiency, thereby promoting ZIF-8 decomposition and accelerating drug release. In vitro tests demonstrated significant antibacterial activity against <i>E. coli</i> and <i>S. aureus</i>, strong anti-inflammatory effects, and excellent cytocompatibility with MC3T3-E1 osteoblast cells. This multifunctional implant surface provides an effective strategy for infection control and bone regeneration in orthopedic applications.</p> Graphical abstract

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Dual-responsive TiO2 nanotube arrays modified with ZIF-8 and CuS for enhanced antibacterial activity and osseointegration

  • 期刊论文

  • 发表日期：

    2026年3月3日

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  • Jiading Zheng,
  • Hongxiu Wang,
  • Jiansong Chen,
  • Hong Zheng,
  • Tao Zhang,
  • Shi Chen,
  • Xiufeng Xiao

摘要

In this study, we developed a dual-stimuli-responsive drug delivery system based on TiO₂ nanotube arrays (TNTs) modified with zeolitic imidazolate framework-8 (ZIF-8) and copper sulfide nanoparticles (CuS) for improved antibacterial efficacy and osseointegration. Vancomycin and CuS were co-loaded into the TNTs via a one-pot synthesis approach, and ZIF-8 served as both a high-capacity drug reservoir and a pH-responsive gatekeeper. The system exhibited rapid and controlled drug release under near-infrared (NIR, 808 nm) irradiation and acidic conditions, mimicking post-surgical infection sites. The CuS nanoparticles enhanced photothermal conversion efficiency, thereby promoting ZIF-8 decomposition and accelerating drug release. In vitro tests demonstrated significant antibacterial activity against E. coli and S. aureus, strong anti-inflammatory effects, and excellent cytocompatibility with MC3T3-E1 osteoblast cells. This multifunctional implant surface provides an effective strategy for infection control and bone regeneration in orthopedic applications.

Graphical abstract