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<p>Zinc-based alloys are emerging as a promising class of biodegradable materials for next-generation orthopedic and cardiovascular implants, offering an ideal balance of corrosion behavior and biological functionality. Despite these advantages, the poor mechanical strength and fatigue resistance of pure zinc remain significant barriers to clinical translation. This review examines recent advancements in alloy design, thermomechanical processing, and advanced manufacturing techniques that enhance both mechanical performance and bio-functionality. Artificial intelligence and computational modeling are also discussed as emerging tools with the potential to support alloy development and aid in optimizing processing parameters. Future directions include patient-specific implant fabrication, multifunctional surface designs, and regulatory strategies to enable safe and effective clinical application.</p>

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Review: zinc alloys for biomedical applications—alloy design, processing techniques, and bio-functional performance

  • 期刊论文

  • 发表日期：

    2026年1月9日

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  • Abhishek Kansal,
  • Nitin Dixit,
  • Sanjeev Kumar,
  • Akshay Dvivedi,
  • Pradeep Kuamr

摘要

Zinc-based alloys are emerging as a promising class of biodegradable materials for next-generation orthopedic and cardiovascular implants, offering an ideal balance of corrosion behavior and biological functionality. Despite these advantages, the poor mechanical strength and fatigue resistance of pure zinc remain significant barriers to clinical translation. This review examines recent advancements in alloy design, thermomechanical processing, and advanced manufacturing techniques that enhance both mechanical performance and bio-functionality. Artificial intelligence and computational modeling are also discussed as emerging tools with the potential to support alloy development and aid in optimizing processing parameters. Future directions include patient-specific implant fabrication, multifunctional surface designs, and regulatory strategies to enable safe and effective clinical application.