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<p>Traditional wound dressings often fail to address the dynamic mechanical and biochemical demands of complex wound microenvironments, necessitating advanced materials with multifunctional adaptability. Herein, a multifunctional composite hydrogel (PCTM) was developed by integrating polyvinyl alcohol, carboxymethyl chitosan, tannic acid, and montmorillonite (MMT) through a synergistic physical crosslinking strategy. The freeze–thaw process, combined with hydrogen bonding and electrostatic interactions, enhanced anti-swelling capacity (equilibrium ratio: 1.11 in PBS). MMT reinforcement significantly improved mechanical robustness, achieving a tensile strength of 994.2&#xa0;kPa, compressive strength of 461.6&#xa0;kPa, and energy dissipation of 15.4&#xa0;kJ/m<sup>3</sup>, ensuring structural stability under repetitive deformations. Dynamic reversible interactions endowed rapid self-healing (75.9% strength recovery) and strong tissue adhesion (26.2&#xa0;kPa), critical for mechanically active wound regions. The hydrogel prepared in this work shows promising potential for biomedical applications, particularly as a skin wound dressing.</p> Graphical abstract <p></p>

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Physically crosslinked, montmorillonite-reinforced hydrogels for self-healing and tough adhesive wound dressings

  • 期刊论文

  • 发表日期：

    2025年12月2日

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  • Mengruo Zhang,
  • Yuwei Zhang,
  • Jia Sun,
  • Wenkai Feng,
  • Rao Li

摘要

Traditional wound dressings often fail to address the dynamic mechanical and biochemical demands of complex wound microenvironments, necessitating advanced materials with multifunctional adaptability. Herein, a multifunctional composite hydrogel (PCTM) was developed by integrating polyvinyl alcohol, carboxymethyl chitosan, tannic acid, and montmorillonite (MMT) through a synergistic physical crosslinking strategy. The freeze–thaw process, combined with hydrogen bonding and electrostatic interactions, enhanced anti-swelling capacity (equilibrium ratio: 1.11 in PBS). MMT reinforcement significantly improved mechanical robustness, achieving a tensile strength of 994.2 kPa, compressive strength of 461.6 kPa, and energy dissipation of 15.4 kJ/m3, ensuring structural stability under repetitive deformations. Dynamic reversible interactions endowed rapid self-healing (75.9% strength recovery) and strong tissue adhesion (26.2 kPa), critical for mechanically active wound regions. The hydrogel prepared in this work shows promising potential for biomedical applications, particularly as a skin wound dressing.

Graphical abstract