<p>The reactive DC combinatorial sputtering method deposited molybdenum oxide (MoO) and tantalum oxide (TaO) thin films on Ti substrates. Two compositions of thin films with and without MoO were prepared as composite thin films. The first film is with a composite of TaO and niobium oxide (Nb₂O₅) was fabricated using the co-sputtering method (TaNbMoO-0) of thickness 1.64&#xa0;mm, and the second coating is a composition of Ta, Nb, and Mo oxides thin film with a combinatorial sputtering method (TaNbMoO-1) of thickness 1.72&#xa0;mm. XRD and TEM were employed to analyze the crystallographic structure and confirm the amorphous nature of the TaNbMoO-1 coating. The SEM analysis was used to analyze the surface morphology and thickness of the coatings, which showed nanoneedles and uniform granular surfaces with smooth morphology. The coatings’ elemental compositions were evaluated by XPS, confirming the presence of Ta, Nb, Mo, and O. The contact angle of the coatings by the sessile drop technique displayed a hydrophobic nature of the coatings. The MoO-incorporated coatings showed greater corrosion resistance, which was enhanced with the increase in corrosion potential (<i>E</i>_corr) compared to the bare Ti. The bioactivity studies of the specimens were done by immersing them in SBF for 21&#xa0;days, revealing a Ca/P ratio of 1.3 and 1.507 for both coatings. The blood compatibility studies were done by direct blood contact with the specimen, and the results showed a greater time of blood clotting of TaNbMoO-1, which was 60&#xa0;min compared to TaNbMoO-0. Cytotoxicity assays (MTT) showed high cell viability for both coatings, with TaNbMoO-1 reaching up to 106% viability at day 6, demonstrating excellent biocompatibility. The biocompatibility of the specimens is evaluated by the cell proliferation and morphology, which revealed improved viability and attachment of cells on the Mo-containing coating.</p> Graphical abstract <p></p>