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<p>Nanomaterials with photothermal conversion effect have broad application prospects, especially in the cancer photothermal therapy. However, traditional gold&#xa0;nanoparticles usually have wavelength selective photothermal response to light, but do not possess environmental responsiveness. Environmental responsive nanomaterials have been widely applied in cancer treatment, especially the nanomaterials with reduction environment responsiveness. In this study, we have synthesized a novel nanoparticle MnO<sub>2</sub>@Cu<sub>2</sub>O@AuR with bilayer-coated gold&#xa0;nanorods (AuRs) which were prepared by sequentially coating cuprous oxide and manganese oxide on the surface of AuRs. The nanomaterials exhibited photothermal conversion effects under reducing thiol conditions while showing insignificant effects under non-reducing conditions. At the same time, the structure and environmental response of photothermal effect of synthetic nanomaterials are systematically studied. The experiment results on heating efficiency showed that in a 5&#xa0;mM glutathione solution, nanoparticles MnO<sub>2</sub>@Cu<sub>2</sub>O@AuR with a concentration of 25 ug/mL could heat the solution to 50&#xa0;°C within 3&#xa0;min under 2 W 808&#xa0;nm laser irradiation. Therefore, this study provides a new strategy for the development of environment responsive photothermal nanomaterials and the novel&#xa0;ideas of cancer photothermal therapy.</p> Graphical Abstract <p></p>

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Synthesis of bilayer-coated gold nanorods with environmental responsiveness of photothermal effects

  • 期刊论文

  • 发表日期：

    2026年4月6日

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  • Chunhua Niu,
  • Qing Miao,
  • Linxiang Zhou,
  • Kai Chen,
  • Wanjun Gu,
  • Nana Li,
  • Zhongwei Wang,
  • Zhong Wei,
  • Xiaokang Zhang

摘要

Nanomaterials with photothermal conversion effect have broad application prospects, especially in the cancer photothermal therapy. However, traditional gold nanoparticles usually have wavelength selective photothermal response to light, but do not possess environmental responsiveness. Environmental responsive nanomaterials have been widely applied in cancer treatment, especially the nanomaterials with reduction environment responsiveness. In this study, we have synthesized a novel nanoparticle MnO2@Cu2O@AuR with bilayer-coated gold nanorods (AuRs) which were prepared by sequentially coating cuprous oxide and manganese oxide on the surface of AuRs. The nanomaterials exhibited photothermal conversion effects under reducing thiol conditions while showing insignificant effects under non-reducing conditions. At the same time, the structure and environmental response of photothermal effect of synthetic nanomaterials are systematically studied. The experiment results on heating efficiency showed that in a 5 mM glutathione solution, nanoparticles MnO2@Cu2O@AuR with a concentration of 25 ug/mL could heat the solution to 50 °C within 3 min under 2 W 808 nm laser irradiation. Therefore, this study provides a new strategy for the development of environment responsive photothermal nanomaterials and the novel ideas of cancer photothermal therapy.

Graphical Abstract