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<p>In this paper, the silk fibroin was blended with nano-sized cesium tungsten bronze particles (Cs<sub>x</sub>WO<sub>3</sub> NPs), and the RSF/Cs<sub>x</sub>WO<sub>3</sub> NPs composite films with different mass fractions were prepared by flow-casting method. The mechanical properties of 3wt%-RSF/Cs<sub>x</sub>WO<sub>3</sub> NPs composite film are the best, the elongation at break and the strength at break are 298.32 ± 13.2% and 8.11 ± 0.47&#xa0;MPa, respectively, which are 170.3% and 83.5% higher than that of blank film. FTIR and WAXD analysis show that Cs<sub>x</sub>WO<sub>3</sub> NPs reduces the <i>β</i>-sheet and crystallinity of RSF films, which may be the potential reason for the improvement of mechanical properties of RSF/Cs<sub>x</sub>WO<sub>3</sub> NPs composite films. The composite film has good photoinduced heating performance, in which the temperature reaches 79.0&#xa0;°C from 19.9&#xa0;°C within 1&#xa0;min and about 94.0&#xa0;°C within 10&#xa0;min under xenon lamp (300&#xa0;W, <i>λ</i> ≥ 420&#xa0;nm). When tetracycline hydrochloride (Th) was loaded into the composite membrane, it was found that the Cs<sub>x</sub>WO<sub>3</sub> NPs/ RSF/Th composite membrane had good antibacterial activity against <i>Escherichia coli and Staphylococcus aureus</i>, and the sustained release performance of the drug was better than that of the blank membrane. This functional composite membrane has great application potential and development prospects in the medical wound dressing and antibacterial materials.</p> Graphical abstract <p></p>

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Drug release effect of regenerated silk fibroin/nano cesium tungsten bronze composite film with photothermal conversion performance

  • 期刊论文

  • 发表日期：

    2025年4月27日

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  • Xinyi Wu,
  • Huihui Li,
  • Gang Deng,
  • Yi Fang,
  • Lin Ma,
  • Guohua Wu

摘要

In this paper, the silk fibroin was blended with nano-sized cesium tungsten bronze particles (CsxWO3 NPs), and the RSF/CsxWO3 NPs composite films with different mass fractions were prepared by flow-casting method. The mechanical properties of 3wt%-RSF/CsxWO3 NPs composite film are the best, the elongation at break and the strength at break are 298.32 ± 13.2% and 8.11 ± 0.47 MPa, respectively, which are 170.3% and 83.5% higher than that of blank film. FTIR and WAXD analysis show that CsxWO3 NPs reduces the β-sheet and crystallinity of RSF films, which may be the potential reason for the improvement of mechanical properties of RSF/CsxWO3 NPs composite films. The composite film has good photoinduced heating performance, in which the temperature reaches 79.0 °C from 19.9 °C within 1 min and about 94.0 °C within 10 min under xenon lamp (300 W, λ ≥ 420 nm). When tetracycline hydrochloride (Th) was loaded into the composite membrane, it was found that the CsxWO3 NPs/ RSF/Th composite membrane had good antibacterial activity against Escherichia coli and Staphylococcus aureus, and the sustained release performance of the drug was better than that of the blank membrane. This functional composite membrane has great application potential and development prospects in the medical wound dressing and antibacterial materials.

Graphical abstract