<p>The effect of severe plastic deformation by all-round pressing technique on the structural-phase state, mechanical and acoustic properties of near α titanium alloy Ti-4Al-2V was studied. The treatment resulted in the development of a uniform globular ultrafine-grained structure within the alloy with an average structural element size of approximately 0.4&#xa0;μm. This led to a notable enhancement in both mechanical and acoustic properties of the alloy. Specifically, the yield stress and ultimate strength of the alloy demonstrated an increase of approximately 70% compared to its coarse-grained state while maintaining acceptable ductility. Furthermore, examination of the acoustic characteristics revealed a decrease in the resonant frequency in stepped waveguides made of the ultrafine-grained alloy as opposed to their coarse-grained counterparts. This shift is attributed to potential alterations in the Young’s modulus of the alloy post-treatment, influenced by changes in its phase composition and the presence of numerous nonequilibrium grain boundaries. Notably, waveguides made from the ultrafine-grained alloy demonstrated a higher tolerance to input ultrasound power, with failure occurring at 1.5–2 times the level of acoustic energy required for their coarse-grained counterparts. Moreover, under cyclic loading conditions, the operational life of these waveguides significantly increased when subjected to higher power densities of ultrasound within the acoustic system.</p>