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<p>In this investigation, we designed and synthesized new chitosan-coated selenium nanoparticles functionalized with a peptide PG-6/PTW protein complex polysaccharide loaded with TPZ/RAP. The particle size and zeta potential of cSeNPs@TPZ/RAP were 71.06 ± 5.63&#xa0;nm and − 17.1 ± 4.35&#xa0;mV, respectively. These nanoparticles demonstrated a desirable size distribution and excellent stability. In addition, we investigated the protective impact of cSeNPs@TPZ/RAP on PC12 cell lines cytotoxicity induced by hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and the primary mechanism. Moreover, our study revealed that cSeNPs@TPZ/RAP effectively reduced the excessive generation of reactive oxygen species (ROS) to protect against mitochondrial dysfunction. The impact of cSeNPs@TPZ/RAP on recovering function following SCI was assessed using the Basso–Beattie–Bresnahan (BBB) locomotor scale and inclined plane test. The hematoxylin–eosin staining results further demonstrated that cSeNPs@TPZ/RAP exhibited a neuroprotective effect in rats with spinal cord injury (SCI). The finding indicates that cSeNPs@TPZ/RAP has the potential to be advanced as a highly effective nanomedicine for the treatment of spinal cord injuries.</p> Graphical abstract <p></p>

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Fabrication of chitosan-coated selenium nanoparticles improved anti-inflammation in the treatment of spinal cord injury by reduced ROS and mitochondrial potential

  • 期刊论文

  • 发表日期：

    2025年5月2日

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  • Zhaofei Wang,
  • Xiangfei Liu,
  • Guoyun He,
  • Xiang Xu,
  • Yansong Wang

摘要

In this investigation, we designed and synthesized new chitosan-coated selenium nanoparticles functionalized with a peptide PG-6/PTW protein complex polysaccharide loaded with TPZ/RAP. The particle size and zeta potential of cSeNPs@TPZ/RAP were 71.06 ± 5.63 nm and − 17.1 ± 4.35 mV, respectively. These nanoparticles demonstrated a desirable size distribution and excellent stability. In addition, we investigated the protective impact of cSeNPs@TPZ/RAP on PC12 cell lines cytotoxicity induced by hydrogen peroxide (H2O2) and the primary mechanism. Moreover, our study revealed that cSeNPs@TPZ/RAP effectively reduced the excessive generation of reactive oxygen species (ROS) to protect against mitochondrial dysfunction. The impact of cSeNPs@TPZ/RAP on recovering function following SCI was assessed using the Basso–Beattie–Bresnahan (BBB) locomotor scale and inclined plane test. The hematoxylin–eosin staining results further demonstrated that cSeNPs@TPZ/RAP exhibited a neuroprotective effect in rats with spinal cord injury (SCI). The finding indicates that cSeNPs@TPZ/RAP has the potential to be advanced as a highly effective nanomedicine for the treatment of spinal cord injuries.

Graphical abstract