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Introduction <p>Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode–tissue interface. We evaluated the effects of application repetition and inter-application intervals on temperature rise and lesion depth using a circular-shaped PFA catheter.</p> Methods and Results <p>In an in vitro potato model, a circular-shaped PFA catheter was tested under five settings: 1×, 2×, 2× with a 10-s interval, 4×, and 4× with a 10-s interval. Maximum electrode surface temperature was measured using a thermal camera, and lesion depth was assessed by TTC staining (<i>n</i> = 5 per setting). Temperature increased significantly with application repetition and was attenuated by a 10-s interval (overall <i>P</i> &lt; 0.0001). Lesion depth also increased with repetition (overall <i>P</i> &lt; 0.0001), but did not differ significantly between interval and no-interval conditions at equal application numbers.</p> Conclusion <p>In this simplified in vitro model, a short inter-application interval was associated with attenuation of temperature rise during repeated PFA delivery, while lesion depth was not significantly reduced.</p>

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Impact of application repetition on Joule heating and lesion formation using a circular-shaped pulsed field catheter

  • 期刊论文

  • 发表日期：

    2026年6月23日

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  • Mizuki Okumura,
  • Shintaro Yamagami,
  • Masaya Akiyama,
  • Yuta Nakano,
  • Yu Amano,
  • Toyoki Okuda,
  • Tsukasa Motoyoshi,
  • Ryuki Chatani,
  • Hirokazu Kondo,
  • Toshihiro Tamura

摘要

Introduction

Pulsed field ablation (PFA) is a non-thermal ablation modality, but repeated high-voltage applications can still cause Joule heating at the electrode–tissue interface. We evaluated the effects of application repetition and inter-application intervals on temperature rise and lesion depth using a circular-shaped PFA catheter.

Methods and Results

In an in vitro potato model, a circular-shaped PFA catheter was tested under five settings: 1×, 2×, 2× with a 10-s interval, 4×, and 4× with a 10-s interval. Maximum electrode surface temperature was measured using a thermal camera, and lesion depth was assessed by TTC staining (n = 5 per setting). Temperature increased significantly with application repetition and was attenuated by a 10-s interval (overall P < 0.0001). Lesion depth also increased with repetition (overall P < 0.0001), but did not differ significantly between interval and no-interval conditions at equal application numbers.

Conclusion

In this simplified in vitro model, a short inter-application interval was associated with attenuation of temperature rise during repeated PFA delivery, while lesion depth was not significantly reduced.