Scholarlink

Introduction <p>Left bundle branch pacing (LBBP) is an alternative to conventional biventricular pacing for cardiac resynchronization therapy (CRT).</p> Methods <p>A 76-year-old male was referred for CRT via left bundle branch pacing (LBBP). We present the real-time characterization of the transition from intrinsic left bundle branch block (LBBB) to sequential pacing modalities: right ventricular septal pacing (RVSP), left ventricular septal pacing (LVSP), and finally LBBP. Epicardial activation maps from electrocardiographic imaging (ECGi) and low-frequency (LF) QRS analysis were used to provide complementary insights into inter- and intraventricular synchrony.</p> Results <p>LVSP, LBBP, and anodal capture improved activation compared with baseline, with LBBP achieving the greatest improvements in interventricular and LV intraventricular synchrony despite higher RV dispersion.</p> Conclusion <p>These findings highlight ECGi and LF QRS as valuable tools to guide CRT.</p> Graphical Abstract <p>Body surface potentials were recorded using a 128-electrode array covering the anterior and posterior torso. Ventricular ECGi maps and derived markers were then computed. A standard 12-lead ECG was simultaneously obtained from 10 conventional electrodes, and the ventricular activation sequence and precordial activation delay (pAD) were calculated. Both baseline and different pacing locations were analyzed.</p> <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Real-time assessment of inter and intraventricular synchrony in cardiac resynchronization therapy with left bundle branch pacing using ECGi and low-frequency QRS analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月14日

查看全文
  • Clara Sales-Belles,
  • Ana Mincholé,
  • Mercedes Cabrera-Ramos,
  • Jorge Melero-Polo,
  • Esther Pueyo,
  • Javier Ramos Maqueda

摘要

Introduction

Left bundle branch pacing (LBBP) is an alternative to conventional biventricular pacing for cardiac resynchronization therapy (CRT).

Methods

A 76-year-old male was referred for CRT via left bundle branch pacing (LBBP). We present the real-time characterization of the transition from intrinsic left bundle branch block (LBBB) to sequential pacing modalities: right ventricular septal pacing (RVSP), left ventricular septal pacing (LVSP), and finally LBBP. Epicardial activation maps from electrocardiographic imaging (ECGi) and low-frequency (LF) QRS analysis were used to provide complementary insights into inter- and intraventricular synchrony.

Results

LVSP, LBBP, and anodal capture improved activation compared with baseline, with LBBP achieving the greatest improvements in interventricular and LV intraventricular synchrony despite higher RV dispersion.

Conclusion

These findings highlight ECGi and LF QRS as valuable tools to guide CRT.

Graphical Abstract

Body surface potentials were recorded using a 128-electrode array covering the anterior and posterior torso. Ventricular ECGi maps and derived markers were then computed. A standard 12-lead ECG was simultaneously obtained from 10 conventional electrodes, and the ventricular activation sequence and precordial activation delay (pAD) were calculated. Both baseline and different pacing locations were analyzed.