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Background <p>The QDOT Micro catheter allows to perform a very high-power short-duration ablation that produces wider and shallower lesions. This study aims to corroborate the evidences on the safety, acute and long-term efficacy of this catheter by providing a large real-world dataset.</p> Methods <p>The AIR HPSD Registry is a multicentric prospective registry across 26 European centers that enrolled consecutive atrial fibrillation (AF) patients undergoing their first pulmonary vein (PV) isolation. In all patients a wide antrum circumferential ablation aimed at PV isolation was performed using the QDOT Micro catheter in QMode+ (90 w for 4&#xa0;s) for the whole ablation or in a hybrid mode (QMode + for the posterior wall and QMode guided by ablation index for the anterior wall), according to the operators’ preference.</p> Results <p>Overall, 982 patients have been enrolled, 38% of patients were ablated with the QMode + solely and 62% with a hybrid modality. The fluoroscopy time was higher in the hybrid group (396 ± 493&#xa0;s vs. 138 ± 238&#xa0;s, <i>p</i> &lt; 0.001) and similarly the procedural time (112 ± 41&#xa0;min vs. 96 ± 36&#xa0;min, <i>p</i> = 0.01). The complications (1.8%) were similar between groups (1.1% in Qmode+ group vs. 2.3% in hybrid group, <i>p</i> = 0.3). The freedom from AF/AT recurrence was similar between groups (88% hybrid group vs. 90% Qmode+ group, p = ns) and higher in paroxysmal than in persistent patients (90% vs. 81%, <i>p</i> &lt; 0.001).</p> Conclusion <p>The QDOT Micro catheter demonstrated high efficiency, safety, and effectiveness in achieving PV isolation in patients undergoing their first ablation for paroxysmal or persistent AF.</p> Graphical Abstract <p></p>

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Very high-power short duration radiofrequency ablation to achieve pulmonary vein isolation: the AIR HPSD registry

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  • 发表日期：

    2026年3月31日

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  • Teresa Strisciuglio,
  • Roberto Mantovan,
  • Francesco Solimene,
  • Sara Poggi,
  • Antoine Lepillier,
  • Andrea Giomi,
  • Marco Scaglione,
  • Massimo Grimaldi,
  • Marzia Giaccardi,
  • Luca Rossi,
  • Saverio Iacopino,
  • Piotr Kulakowski,
  • Tomasz Krynski,
  • Matteo Anselmino,
  • Antonio Dello Russo,
  • Paolo Compagnucci,
  • Claire A. Martin,
  • Kiran Kang,
  • Adrian Gwizdala,
  • Marcello Anders Piacenti,
  • Maria Luisa Loricchio,
  • Graziana Viola,
  • Giulio Zucchelli,
  • Kaspars Kupics,
  • Luca Rebellato,
  • Procolo Marchese,
  • Claudio Pandozi,
  • Alexandre Bodin,
  • Giacomo Mugnai,
  • Gemma Palergonio,
  • Maria Lucia Narducci,
  • Marco Gallucci,
  • Vincenzo Schillaci,
  • Sarah Zeriouh,
  • Ieva Ansaberga,
  • Kristine Jubele,
  • Giuseppe Stabile

摘要

Background

The QDOT Micro catheter allows to perform a very high-power short-duration ablation that produces wider and shallower lesions. This study aims to corroborate the evidences on the safety, acute and long-term efficacy of this catheter by providing a large real-world dataset.

Methods

The AIR HPSD Registry is a multicentric prospective registry across 26 European centers that enrolled consecutive atrial fibrillation (AF) patients undergoing their first pulmonary vein (PV) isolation. In all patients a wide antrum circumferential ablation aimed at PV isolation was performed using the QDOT Micro catheter in QMode+ (90 w for 4 s) for the whole ablation or in a hybrid mode (QMode + for the posterior wall and QMode guided by ablation index for the anterior wall), according to the operators’ preference.

Results

Overall, 982 patients have been enrolled, 38% of patients were ablated with the QMode + solely and 62% with a hybrid modality. The fluoroscopy time was higher in the hybrid group (396 ± 493 s vs. 138 ± 238 s, p < 0.001) and similarly the procedural time (112 ± 41 min vs. 96 ± 36 min, p = 0.01). The complications (1.8%) were similar between groups (1.1% in Qmode+ group vs. 2.3% in hybrid group, p = 0.3). The freedom from AF/AT recurrence was similar between groups (88% hybrid group vs. 90% Qmode+ group, p = ns) and higher in paroxysmal than in persistent patients (90% vs. 81%, p < 0.001).

Conclusion

The QDOT Micro catheter demonstrated high efficiency, safety, and effectiveness in achieving PV isolation in patients undergoing their first ablation for paroxysmal or persistent AF.

Graphical Abstract