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Introduction <p>Premature ventricular complexes (PVCs) from intracavitary structures, such as papillary muscles and the moderator band, can be challenging to treat. Pulsed field ablation (PFA) offers a novel strategy for treating these arrhythmias.</p> Methods <p>Between 2023 and 2024, three patients with intracavitary PVCs (two with PVC-mediated ventricular fibrillation) underwent PFA at a tertiary referral centre. Electroanatomic mapping was performed and, with intracardiac echocardiography (ICE) guidance, PFA was delivered using a pentaspline Farapulse catheter, with adjuvant radiofrequency (RF) ablation as needed.</p> Results <p>All patients had successful abolition of PVCs. PFA delivery was feasible and safe, with excellent success despite prior RF ablation failures though one patient required adjuvant RF ablation. The only complication was a persistent right bundle branch block (RBBB) after PFA delivery to the moderator band. Follow-up showed significant reductions in PVC burden and no further ventricular fibrillation (VF) episodes. The mean procedural duration was 153.67 ± 31.71 min, and the mean fluoroscopy time was 14.38 ± 6.74 min.</p> Conclusion <p> This is a preliminary proof of concept report for ablation of PVCs from intracavitary structures, warranting further validation studies.</p>

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Pulsed field ablation of ventricular arrhythmias arising from intracavitary structures: insights from a clinical case series

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月2日

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  • Kasun De Silva,
  • Tai Chung So,
  • Samual Turnbull,
  • Max Bickley,
  • Kenji Hashimoto,
  • Ashwin Bhaskaran,
  • Saurabh Kumar

摘要

Introduction

Premature ventricular complexes (PVCs) from intracavitary structures, such as papillary muscles and the moderator band, can be challenging to treat. Pulsed field ablation (PFA) offers a novel strategy for treating these arrhythmias.

Methods

Between 2023 and 2024, three patients with intracavitary PVCs (two with PVC-mediated ventricular fibrillation) underwent PFA at a tertiary referral centre. Electroanatomic mapping was performed and, with intracardiac echocardiography (ICE) guidance, PFA was delivered using a pentaspline Farapulse catheter, with adjuvant radiofrequency (RF) ablation as needed.

Results

All patients had successful abolition of PVCs. PFA delivery was feasible and safe, with excellent success despite prior RF ablation failures though one patient required adjuvant RF ablation. The only complication was a persistent right bundle branch block (RBBB) after PFA delivery to the moderator band. Follow-up showed significant reductions in PVC burden and no further ventricular fibrillation (VF) episodes. The mean procedural duration was 153.67 ± 31.71 min, and the mean fluoroscopy time was 14.38 ± 6.74 min.

Conclusion

This is a preliminary proof of concept report for ablation of PVCs from intracavitary structures, warranting further validation studies.