Cardioneuroablation for the management of patients with recurrent vasovagal syncope and symptomatic bradyarrhythmias: the CNA-FWRD Registry

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发表日期：

2024年3月18日

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Tolga Aksu,
Roderick Tung,
Tom De Potter,
Timothy M. Markman,
Pasquale Santangeli,
Jeanne du Fay de Lavallaz,
Jeffrey R. Winterfield,
Tina Baykaner,
Daniel Alyesh,
Jacqueline E. Joza,
Rakesh Gopinathannair,
Patrick Badertscher,
Duc H. Do,
Ayman Hussein,
Jose Osorio,
Thomas Dewland,
Alexander Perino,
Albert J. Rodgers,
Christopher DeSimone,
Alberto Alfie,
Brett D. Atwater,
David Singh,
Kapil Kumar,
Jonathan Salcedo,
Jason S. Bradfield,
Gaurav Upadhyay,
Nitesh Sood,
Parikshit S. Sharma,
Sandeep Gautam,
Vineet Kumar,
Alexander Romeno Janner Dal Forno,
Christopher E. Woods,
Moshe Rav-Acha,
Chiara Valeriano,
Sunil Kapur,
Andres Enriquez,
Sri Sundaram,
Michael Glikson,
Edward Gerstenfeld,
Jonathan Piccini,
Wendy S. Tzou,
William Sauer,
Andre d’Avila,
Kalyanam Shivkumar,
Henry D. Huang

摘要

Background

Cardioneuroablation has been emerging as a potential treatment alternative in appropriately selected patients with cardioinhibitory vasovagal syncope (VVS) and functional AV block (AVB). However the majority of available evidence has been derived from retrospective cohort studies performed by experienced operators.

Methods

The Cardioneuroablation for the Management of Patients with Recurrent Vasovagal Syncope and Symptomatic Bradyarrhythmias (CNA-FWRD) Registry is a multicenter prospective registry with cross-over design evaluating acute and long-term outcomes of VVS and AVB patients treated by conservative therapy and CNA.

Results

The study is a prospective observational registry with cross-over design for analysis of outcomes between a control group (i.e., behavioral and medical therapy only) and intervention group (Cardioneuroablation). Primary and secondary outcomes will only be assessed after enrollment in the registry. The follow-up period will be 3 years after enrollment.

Conclusions

There remains a lack of prospective multicentered data for long-term outcomes comparing conservative therapy to radiofrequency CNA procedures particularly for key outcomes including recurrence of syncope, AV block, durable impact of disruption of the autonomic nervous system, and long-term complications after CNA. The CNA-FWRD registry has the potential to help fill this information gap.