<p>Understanding how childhood disability affects maternal employment is essential for designing inclusive labor and social policies. In developing countries, labor markets are informal and segmented, and care responsibilities largely fall on households. Within families, cultural norms often place the burden of care primarily on women. In Argentina, one in every ten children lives with a disability, making this analysis particularly relevant. A child’s disability increases child care demands, causing two opposing effects on the mother’s labor supply: while some types require additional time spent reducing labor supply, others require additional expenses increasing labor supply. This paper studies the effect of a child’s disability on mothers’ labor supply using data from the 2019–20 IPUMS MICS of Argentina. Four measures of disability are used: functional disabilities (based on Washington Group criteria); functional difficulties for seeing, hearing, or walking; difficulties in the remaining functional domains; and disability certificate or pension. The results suggest that having a child with a disability certificate/pension reduces a mother’s probability of participating in the labor force. No significant effect is found for mothers of a child with a functional disability. However, this arises from two opposing effects: a negative effect on mothers’ labor supply of children with difficulties for seeing, hearing, or walking and a positive effect on mothers of children with difficulties in the remaining functional domains. The evidence also shows heterogeneous effects depending on the mother’s education. The (dis)incentive to participate is present for non-graduated mothers, while the effect is not statistically significant for graduated ones.</p>