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<p>The study of brain activity and its function requires the development of computational models alongside experimental investigations to explore different effects of multiple mechanisms at play in the central nervous system. Chemical neuromodulators, such as dopamine, play central roles in regulating the dynamics of neuronal populations. In this work, we propose a modular framework to capture the effects of neuromodulators at the neural mass level. Using this framework, we formulate a specific model for dopamine dynamics affecting D1-type receptors. We detail the dynamical repertoire associated with dopamine concentration evolution and characterize the transitions across qualitatively different oscillatory states as a function of relevant parameters, along with the variations in frequency of the emergent multi-scale oscillations.</p>

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A next generation neural mass model with neuromodulation

  • 期刊论文

  • 发表日期：

    2026年2月12日

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  • Damien Depannemaecker,
  • Chloé Duprat,
  • Gabriele Casagrande,
  • Marisa Saggio,
  • Anastasios Polykarpos Athanasiadis,
  • Marianna Angiolelli,
  • Carola Sales Carbonell,
  • Huifang Wang,
  • Spase Petkoski,
  • Pierpaolo Sorrentino,
  • Anthony Randal McIntosh,
  • Hiba Sheheitli,
  • Viktor Jirsa

摘要

The study of brain activity and its function requires the development of computational models alongside experimental investigations to explore different effects of multiple mechanisms at play in the central nervous system. Chemical neuromodulators, such as dopamine, play central roles in regulating the dynamics of neuronal populations. In this work, we propose a modular framework to capture the effects of neuromodulators at the neural mass level. Using this framework, we formulate a specific model for dopamine dynamics affecting D1-type receptors. We detail the dynamical repertoire associated with dopamine concentration evolution and characterize the transitions across qualitatively different oscillatory states as a function of relevant parameters, along with the variations in frequency of the emergent multi-scale oscillations.