<p>Parenting behavior among adolescents who are depressed and engage in non-suicidal self-injury (NSSI) has received considerable attention, with research suggesting that recognizing parenting differences across subgroups (via person-centered approaches) is key to addressing the diverse needs of these vulnerable adolescents.. This study aimed to examine the profiles of parenting behavior and explore the correlation between different parenting profiles and NSSI behavior and its function in a sample of adolescents with depression. Data were collected from 215 adolescents (aged 12–18 years) with depression disoeder in China. Latent profile analysis was used to investigate the parenting profiles. Three potential parenting profiles were identified: Three profiles of parenting style were defined as authoritative parenting (47.6% in father, 53.5% in mother), mixed parenting (34.4% in father, 33.8% in mother), and strict parenting (17.9% in father, 12.6% in mother). The scores of NSSI behavior were significantly higher in adolescents with strict parents than in adolescents with authoritative parents (<i>P</i> &lt; 0.01). NSSI behavior scores are highest in adolescents with parents using distinctly different parenting styles (<i>P</i> &lt; 0.001).The Intrapersonal function score on the NSSI is significantly higher in adolescents with strict parenting style parents (one parent or both parents) (<i>P</i> &lt; 0.001)The current study indicated that different profiles and patterns of parenting behavior were significantly associated with the severity of NSSI behaviors and functions among adolescents with depression.</p>